jak3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10009	JAK3-IN-7		JAK
	JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ...		JAK
T5492	JAK3-IN-6		JAK
	JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM		JAK
T67754	JAK3-IN-14		FLT
	JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.		FLT
T64370	JI6	JAK3 Inhibitor VI	FLT
	JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s ...		FLT
T1985	WHI-P154	Jak3 inhibitor ii	Apoptosis , EGFR , VEGFR , JAK , Src
	WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.		Apoptosis , EGFR , VEGFR , JAK , Src
T2045	JANEX-1	Jak3 inhibitor I,WHI-P131	JAK
	JANEX-1 (Jak3 inhibitor I) is a cell-permeable, reversible, effective, ATP-competitive, and selective inhibitor of JAK3 (IC50: 78 μM); little inhibitory against JAK1/2, or Zap/Syk or SRC tyrosine kinases.		JAK
T9811	JAK3-IN-11
	JAK3-IN-11 (Compound 12) exhibits potent, noncytotoxic, irreversible, orally active JAK3 inhibitory activity (IC50 = 1.7 nM) with an excellent selectivity profile (>588-fold compared to other JAK isoforms), covalently bi...
T6145	ZM39923 hydrochloride	JAK3 Inhibitor IV,ZM 39923 HCl	EGFR , Others , JAK
	ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.		EGFR , Others , JAK
T9813	JAK3/BTK-IN-2		JAK , BTK
	JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor. JAK3/ BTk-in-2 inhibits both BTK and JAK3, which are two important targets IN autoimmune diseases. JAK3/ BTk-in-2 simultaneously inhibits the BTK/JAK3 signaling pathway, sho...		JAK , BTK
T9814	JAK3/BTK-IN-1		JAK , BTK
	JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important targets in autoimmune diseases. JAK3/ BTk-in-1 simultaneously inh...		JAK , BTK
T15607	JAK3-IN-1		Others
	JAK3-IN-1 is a selective and orally active JAK3 inhibitor (IC50: 4.8 nM). JAK3-IN-1 displays over 180-fold more selective for JAK3 than JAK1 (IC50: 896 nM) and JAK2 (IC50: 1050 nM).		Others
T11709	JAK3 covalent inhibitor-1		JAK
	JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs.		JAK
T63749	JAK3-IN-13
	JAK3-IN-13 is a potent, selective, orally active JAK3 inhibitor that acts on NK1 (IC50: 4728 nM), JNK2 (IC50: 2039 nM), JNK3 (IC50: 8 nM), and Tyk2 (IC50: 365 nM). JAK3-IN-13 exhibits anti-tumor effects.
T62114	JAK3-IN-12
	JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.
T61814	JAK3-IN-9
	JAK3-IN-9 is a potent and orally active inhibitor of the Janus kinase 3 (JAK3) enzyme, displaying an impressive IC50 value of 1.7 nM. It exhibits high selectivity towards the JAK3 signaling pathway, making it a valuable ...
T62813	JAK3/BTK-IN-6
	JAK3/BTK-IN-6 is a potent dual inhibitor of BTK (IC50: 0.6 nM) and JAK3 (IC50: 0.4 nM).JAK3/BTK-IN-6 exhibits good metabolic stability in human liver microsomes.JAK3/BTK-IN-6 can be used to study blood and immune disease...
T62234	JAK3/BTK-IN-3
	JAK3/BTK-IN-3 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway has a synergistic effect and JAK3/BTK-IN-3 has sh...
T62153	JAK3/BTK-IN-5
	JAK3/BTK-IN-5 is a potent inhibitor of JAK3/BTK. where BTK and JAK3 are two key targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway has a synergistic effect and JAK3/BTK-IN-5 has po...
T62553	JAK3/BTK-IN-4
	JAK3/BTK-IN-4 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signaling pathway has a synergistic effect and JAK3/BTK-IN-4 has pot...
T2460	JAK 3 inhibitor IV	ZM 39923 hydrochloride,Jak3 inhibitor IV	EGFR , Others , JAK
	JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.		EGFR , Others , JAK