Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 54.00 | |
10 mg | In stock | $ 96.00 | |
25 mg | In stock | $ 179.00 | |
50 mg | In stock | $ 327.00 | |
100 mg | In stock | $ 488.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. |
In vitro | The selectivity of Rotigotine for D3 (pKi 9.2) receptors is higher 10-fold than D2/D4/D5 (pKi 8.5-8.0) and 100-fold than D1 receptors (pKi 7.2). Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. In functional studies, Rotigotine behaves as a full agonist at all dopamine receptors but notably, the potency for stimulation of D1 receptors is similar to that for D2/D3 receptors (pEC50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+ toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone. |
Synonyms | JAK3 Inhibitor IV, ZM 39923 HCl |
Molecular Weight | 367.91 |
Formula | C23H25NO·HCl |
CAS No. | 1021868-92-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 8 mg/mL (21.74 mM)
DMSO: 28 mg/mL (76.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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ZM39923 hydrochloride 1021868-92-7 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Others Stem Cells Tyrosine Kinase/Adaptors EGFR JAK JAK3 Inhibitor IV inhibit ZM 39923 ZM 39923 HCl Janus kinase ZM-39923 hydrochloride ZM39923 Hydrochloride ZM-39923 Inhibitor ZM-39923 Hydrochloride ZM 39923 Hydrochloride ZM39923 inhibitor