jak1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T35899	JAK1-IN-8	JAK1-IN-8	JAK
	JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).		JAK
T39314	JAK1/TYK2-IN-1	JAK1/TYK2-IN-1
	JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).
T77504	JAK1/2/3 Inhibitor 1		PKA
	JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines. It inhibits the growth of cancer cells by binding to the c...		PKA
T15606	JAK1-IN-4		JAK
	JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively). JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM).		JAK
T11706	Londamocitinib	AZD4604	JAK
	Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.		JAK
T70877	JAK1-IN-B61
	JAK1-IN-B61 is a JAK1 inhibitor.
T79079	JAK1-IN-11		JAK
	JAK1-IN-11 (compound 11) serves as a potent inhibitor of Janus kinases, exhibiting nanomolar inhibitory concentrations with IC50 values of 0.02 nM (JAK1) and 0.44 nM (JAK2), demonstrating high selectivity for JAK1 over J...		JAK
T79078	JAK1-IN-10		JAK
	JAK1-IN-10 (compound 9), a cyano-substituted cyclic hydrazine derivative, functions as a potent and selective inhibitor of JAK1 [1].		JAK
T62155	JAK1-IN-9
	JAK1-IN-9 (compound 23a) is a potent, selective inhibitor of JAK1, demonstrating an IC50 of 72 nM. It exhibits over 12-fold selectivity against other JAK family members [1].
T64265	JAK1/TYK2-IN-3
	JAK1/TYK2-IN-3 is a selective, potent, orally active dual inhibitor of TYK2 (IC50: 6 nM) and JAK1 (IC50: 37 nM).JAK1/TYK2-IN-3 selectively acts on both JAK2 and JAK3 with IC50 values of 140 nM and 362 nM.JAK1/TYK2 -IN-3 ...
T39113L	Povorcitinib phosphate		JAK
	Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.		JAK
T9195	SHR0302	ARQ252	Apoptosis , JAK
	SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).		Apoptosis , JAK
T12266	Ilginatinib	NS-018	Tyrosine Kinases , JAK
	Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T7503	Upadacitinib	ABT-494	JAK
	Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.		JAK
T12266L2	Ilginatinib hydrochloride	NS-018 hydrochloride	Tyrosine Kinases , JAK
	Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T12266L	Ilginatinib maleate	NS-018 maleate	Tyrosine Kinases , JAK
	Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.		Tyrosine Kinases , JAK
T22338	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	GDC046	Others , JAK
	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.		Others , JAK
T70875	BI-665915
	BI-665915 is a 5-lipoxygenase activating protein inhibitor.
T22142	RO8191	RO4948191,CDM-3008	HCV Protease , HBV , JAK , IFNAR , STAT
	RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.		HCV Protease , HBV , JAK , IFNAR , STAT
T5049	NVP-BSK805	NVP-BSK805 2HCl,BSK 805	Tyrosine Kinases , JAK
	NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.		Tyrosine Kinases , JAK