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Search Results for " ikaros "

10

Compounds

Cat No. Product Name Synonyms Targets
T9809 E3 ligase Ligand 23 Ligand for E3 Ligase
E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.
T60024 CFT7455 Cemsidomide Ligand for E3 Ligase
CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZ...
T73463 NX-2127 NX2127,NX 2127 BTK
NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 ...
T2384 Pomalidomide CC-4047 Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
T74665 KTX-955
KTX-955, a potent IRAK4 degrader, exhibits DC50 values of 5 nM for IRAK4 and 130 nM for Ikaros. It is primarily utilized in anticancer research [1] [2].
T26688 Avadomide HCl Avadomide hydrochloride,CC122, Avadomide HCl,CC-122,CC 122 HCl
Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes de...
T63024 (Rac)-CFT7455
(Rac)-CFT7455 is an Ikaros/Aiolos degradation agent that acts via the ubiquitin proteasome pathway and is able to act on NCIH929.1 cells (GI50: 0.05 nM). (Rac)-CFT7455 is a racemic isomer of CFT7455 and has anticancer ac...
T63771 CC-99282
CC-99282 is a potent, orally active CRBN E3 ligase modulator (CELMoD).CC-99282 acts in combination with CRBN to co-induce effective and targeted degradation of Ikaros and Aiolos.CC-99282 can be used to study non-Hodgkin'...
T74664 KTX-582
KTX-582 is a potent IRAK4 degrader, exhibiting DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros. It efficiently induces apoptosis in MYD88 MT DLBCL and has demonstrated effectiveness in inducing in vivo tumor regression...
T63339 ALV1
ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal pr...
TargetMol