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Search Results for " hedgehog/smoothened "

20

Compounds

Cat No. Product Name Synonyms Targets
T6891 MK-4101 Apoptosis , Hedgehog/Smoothened , Smo
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells.
T9531 MRT-14 Smo
MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.
T2450 SANT-1 SANT 1 Hedgehog/Smoothened , Smo
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T22814 GSA-10 Hedgehog/Smoothened
Smoothened (Smo) receptor agonist
T2825 Cyclopamine 11-Deoxojervine Hedgehog/Smoothened , Endogenous Metabolite , Smo
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T3363 Jervine Iervin,11-Ketocyclopamine,Jerwiny Hedgehog/Smoothened , Smo
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signa...
T3912 Saikosaponin B1 Others
Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.
T15019 CUR61414 Hedgehog/Smoothened
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
T2666 Taladegib LY2940680 Hedgehog/Smoothened , Smo
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
T1779 SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist Hedgehog/Smoothened , Smo
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.
T9532 MRT-81 Others
MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance...
T1926 Sonidegib Erismodegib,NVP-LDE225,LDE225 Hedgehog/Smoothened , Smo
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T63429 SMO-IN-2 Hedgehog/Smoothened
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c...
T40465 SAG dihydrochloride Hedgehog/Smoothened
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo.
T64351 GI-560192 RL-0070933 Smo
GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway.
T15019L CUR61414 hydrochloride CUR61414 hydrochloride (334998-36-6 Free base) Hedgehog/Smoothened
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively...
T23027 MRT-10 Hedgehog/Smoothened
MRT-10 is a Smoothened (Smo) receptor antagonist.
T24754 Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5 Hedgehog/Smoothened
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...
T71299 M-25
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.
T23307 SANT 2 SANT-2 Others
SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM).
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TargetMol