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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1484 | Perindoprilat | Perindoprilate | RAAS , MRP , AChR |
Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor. | |||
T13176 | TNO155 | Batoprotafib | Phosphatase |
TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity. | |||
T4325 | COTI-2 | COTI 2,COTI2 | Apoptosis , p53 |
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity. | |||
T76691 | Monalizumab | IFNAR , Chk | |
Monalizumab is a novel immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab is a humanized monoclonal antibody against NKG2A that induces IFN-γ production, thereby activating natur... | |||
T76890 | Petosemtamab | MCLA 158 | EGFR |
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab... | |||
T9133L | Caroverine | P 201-1 | |
Caroverine is a potential chemotherapeutical agent in HNSCC cell lines. | |||
T16690 | Pyrazofurin | Others | |
Pyrazofurin is a pyrimidine nucleoside analogue, inhibits cell proliferation and DNA synthesis in cells by inhibiting UMP synthase. Pyrazofurin is a sensitive orotate-phosphoribosyltransferase inhibitor (IC50s between 0.... | |||
T76918 | Barecetamab | ||
Barecetamab (ISU-104), a fully human anti-ErbB3 monoclonal antibody, is utilized in researching recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) [1]. | |||
T82188 | HN-1 | ||
HN-1, a 12-mer peptide with specificity for head and neck squamous cell carcinoma (HNSCC), penetrates tumor tissue and facilitates the translocation of agents across cell membranes [1]. | |||
T63050 | JH-XVII-10 | ||
JH-XVII-10 is a selective, orally active and potent inhibitor of DYRK1A (IC50: 3 nM) and DYRK1B (IC50: 5 nM).JH-XVII-10 exhibits antitumor effects in squamous cell carcinoma of the neck (HNSCC) cell lines. | |||
T62790 | JH-XIV-68-3 | ||
JH-XIV-68-3 is a selective inhibitor of the DYRK1A/B macrocycle.JH-XIV-68-3 selectively acts on DYRK1A and its close relative DYRK1B in biochemical and cellular assays.JH-XIV-68-3 has antitumor effects in head and neck s... | |||
T72776 | NR2F1 agonist 1 | ||
NR2F1 agonist 1, a specific nuclear receptor NR2F1 activator, initiates dormancy programs in cancer cells by upregulating NR2F1 and its target genes controlling dormancy. This compound promotes neural crest-like features... | |||
T68663 | GPI-15427 | ||
GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiform... |