her4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5390	BMS-599626 Hydrochloride	AC480 Hydrochloride	HER
	BMS-599626 Hydrochloride (AC480 Hydrochloride) is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 Hy...		HER
T11213	Epertinib hydrochloride	S-22611 hydrochloride	EGFR , HER
	Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s ...		EGFR , HER
T6719	Varlitinib	ASLAN001,ARRY-334543	HER
	Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.		HER
T5398	BMS 599626 2HCl (873837-23-1(HCl))	AC480 dihydrochloride	HER
	BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100-fold to Lck, VEGFR2, c-Kit, MET, etc.		HER
T2303	(S)-Afatinib	BIBW2992	EGFR , HER
	(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively.		EGFR , HER
T6039	TAK-285	TAK285,TAK 285	EGFR , MEK , HER , Aurora Kinase
	TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.		EGFR , MEK , HER , Aurora Kinase
T8758	Poziotinib hydrochloride	HM 781-36B hydrochloride,NOV120101 hydrochloride	EGFR
	Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavaila...		EGFR
T5168	EGFR-IN-12	EGFR Inhibitor	Apoptosis , EGFR
	EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.		Apoptosis , EGFR
T11213L	Epertinib	S-22611	EGFR , HER
	Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor activity.		EGFR , HER
T34760	SYR127063	SYR-127063,BDBM 92454,SYR 127063,BDBM-92454,BDBM92454	EGFR , HER
	SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.		EGFR , HER
T2610L	BMS-599626 2HCL(714971-09-2 Free base)	BMS 599626 dihydrochloride,BMS-599626 2HCL(714971-09-2 Free base),AC480 2HCl	HER
	BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferat...		HER
T2630	Poziotinib	HM781-36B,NOV120101	Apoptosis , EGFR , HER
	Poziotinib (NOV120101)(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).		Apoptosis , EGFR , HER
T62621	Pan-HER-IN-2
	pan-HER-IN-2 (Compound C6) is an orally active, reversible, broad-spectrum HER inhibitor that acts on EGFR (IC50: 0.72 nM), HER4 (IC50: 2.0 nM), EGFRT790M (IC50: 8.2 nM), and L858R (IC50: 75.1 nM). pan-HER-IN-2 induces a...
T2610	BMS-599626	AC480	EGFR , MEK , HER , Src
	BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.		EGFR , MEK , HER , Src
T62047	Pan-HER-IN-1
	pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan- HER inhibitor. pan-HER-IN-1 exhibits IC 50s of 0.38, 1.6, 2.2 and 3.5 nM for EGFR, HER4, EGFR T790M/L858R and HER2, respectively. pan-HER-IN-1 induces apo...
T14677	BMS-690514		EGFR , VEGFR , HER
	BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.		EGFR , VEGFR , HER
T7819	TAS0728		EGFR , HER
	TAS0728 is a HER2 inhibitor, with antitumor activity		EGFR , HER

Compounds

BMS-599626 Hydrochloride

T5390

Synonym: AC480 Hydrochloride

Target: HER

Epertinib hydrochloride

T11213

Synonym: S-22611 hydrochloride

Target: EGFR, HER

Varlitinib

T6719

Synonym: ASLAN001,ARRY-334543

Target: HER

BMS 599626 2HCl (873837-23-1(HCl))

T5398

Synonym: AC480 dihydrochloride

Synonym: TAK285,TAK 285

Target: EGFR, MEK, HER, Aurora Kinase

Poziotinib hydrochloride

T8758

Synonym: HM 781-36B hydrochloride,NOV120101 hydrochloride

Target: EGFR

EGFR-IN-12

T5168

Synonym: EGFR Inhibitor

Target: Apoptosis, EGFR

Synonym: SYR-127063,BDBM 92454,SYR 127063,BDBM-92454,BDBM92454

Target: EGFR, HER

BMS-599626 2HCL(714971-09-2 Free base)

T2610L

Synonym: BMS 599626 dihydrochloride,BMS-599626 2HCL(714971-09-2 Free base),AC480 2HCl

Target: HER

Poziotinib

T2630

Synonym: HM781-36B,NOV120101

Target: Apoptosis, EGFR, HER

Target: EGFR, MEK, HER, Src

Target: EGFR, VEGFR, HER

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00448	HER4/ERBB4 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important...
TMPK-00449	HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important...
TMPY-03021	ErbB4 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	ErbB4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.5 kDa and the accession number is Q99P91.
TMPY-02246	HB-EGF Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolyticall...