fxa — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63239	FXa-IN-1
	FXa-IN-1 is an FXa inhibitor with an IC50 value of 3 nM and a Ki value of 0.7 nM that exhibits good oral bioavailability and half-life (in vivo) and can be used to study thromboembolic diseases.
T10174	5-R-Rivaroxaban		Factor Xa
	5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0.4 nM).		Factor Xa
T4980	Betrixaban maleate		Factor Xa
	Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa.		Factor Xa
T4341	Betrixaban	PRT054021	Factor Xa
	Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel ...		Factor Xa
T0372	Gabexate mesylate	FOY	Factor Xa , Serine Protease , Proteasome
	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh...		Factor Xa , Serine Protease , Proteasome
T1184	Rivaroxaban	BAY 59-7939	Factor Xa , Thrombin
	Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both ...		Factor Xa , Thrombin
T1736	Apixaban	BMS-562247-01	Factor Xa
	Apixaban (BMS-562247-01) is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and pr...		Factor Xa
T22323	Enoxaparin sodium		Thrombin
	Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu...		Thrombin
T31206	Darexaban	YM 150,Darexaban, Tanexaban,YM150	Factor Xa
	Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...		Factor Xa
T4076	Fondaparinux sodium	Natural heparin pentasaccharide Sodium,Fondaparin sodium,SR-90107A,Arixtra	Factor Xa
	Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.		Factor Xa
T2368	Edoxaban Tosylate Monohydrate	DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban	Factor Xa , Thrombin
	Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.		Factor Xa , Thrombin
T4690	Betrixaban hydrochloride(330942-05-7(free base))	PRT054021 hydrochloride	Factor Xa
	Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).		Factor Xa
T29215	Zifaxaban	TY 602,TY602,TY-602	Factor Xa
	Zifaxaban (TY-602) is an orally active, competitive and selective inhibitor of factor Xa (FXa) with an IC50 of 11.1 nM for human FXa.Zifaxaban has a very high affinity, more than 10,000-fold higher than that of other ser...		Factor Xa
T78215	Dechloro Rivaroxaban		Factor Xa , Others
	Dechloro Rivaroxaban is an orally active and highly selective Factor Xa inhibitor.Dechloro Rivaroxaban has a significant inhibitory effect on free FXa in humans.Dechloro Rivaroxaban also has an inhibitory effect on throm...		Factor Xa , Others
T2368L	Edoxaban	Lixiana	Factor Xa , Thrombin
	Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is a...		Factor Xa , Thrombin
T77373	Concizumab	mAb 2021,NN 7415	Others
	Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, thereby blocking the interaction of this domain with the FXa active site. Injecti...		Others
T27318	Fidexaban	CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834	Factor Xa
	Fidexaban (CI1031) is a novel, potent, selective and orally active factor Xa inhibitor that has demonstrated antithrombotic activity in a variety of assays		Factor Xa
T12736	Rivaroxaban-d4	BAY 59-7939 D4	Factor Xa
	Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).		Factor Xa
T27224	DX-9065A HCl hydrate	DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065
	DX-9065A is a factor Xa inhibitor. DX-9065a inhibits proinflammatory events induced by factor Xa and gingipains. DX-9065a is a competitive inhibitor of the Spectrozyme FXa (SpFXa) cleavage by both fXa and prothrombinase ...
T16410	Otamixaban	FXV673	Others
	Otamixaban(FXV673) is an effective (Ki = 0.5 nM), selective, rapid-acting, competitive, and reversible fXa inhibitor. It also effectively inhibits both free and prothrombinase-bound fXa.		Others