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DX-9065A HCl hydrate

Catalog No. T27224 CAS 155204-81-2

Synonyms: DX9065, DX 9065, DX9065A, DX 9065A, DX-9065A, DX-9065

DX-9065A is a factor Xa inhibitor. DX-9065a inhibits proinflammatory events induced by factor Xa and gingipains. DX-9065a is a competitive inhibitor of the Spectrozyme FXa (SpFXa) cleavage by both fXa and prothrombinase with similar K(i) values of approximately 10-20 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DX-9065A HCl hydrate, CAS 155204-81-2

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,870.00
50 mg	10-14 weeks	$ 3,780.00
100 mg	10-14 weeks	$ 5,200.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	DX9065, DX 9065, DX9065A, DX 9065A, DX-9065A, DX-9065
Molecular Weight	571.06
Formula	C26H39ClN4O8
CAS No.	155204-81-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Graff J, Picard-Willems B, Harder S. Monitoring effects of direct FXa-inhibitors with a new one-step prothrombinase-induced clotting time (PiCT) assay: comparative in vitro investigation with heparin, enoxaparin, fondaparinux and DX 9065a. Int J Clin Pharmacol Ther. 2007 Apr;45(4):237-43. PubMed PMID: 17474542. 2. Fujii Y, Takahashi M, Morita H, Kikuchi H, Aramaki Y, Amidon GL. Characteristics of gastrointestinal absorption of DX-9065a, a new synthetic anticoagulant. Drug Metab Pharmacokinet. 2007 Feb 25;22(1):26-32. PubMed PMID: 17329908. 3. Murayama N, Nakaoka M, Sudo K. Contribution of lysosomes to concentrative uptake of DX-9065a into rat liver. J Pharm Sci. 2006 Aug;95(8):1763-70. PubMed PMID: 16795022. 4. Matsushita K, Imamura T, Tancharoen S, Tatsuyama S, Tomikawa M, Travis J, Potempa J, Torii M, Maruyama I. Selective inhibition of Porphyromonas gingivalis growth by a factor Xa inhibitor, DX-9065a. J Periodontal Res. 2006 Jun;41(3):171-6. PubMed PMID: 16677284.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DX-9065A HCl hydrate 155204-81-2 DX9065 DX 9065 DX9065A DX-9065A HCl Hydrate DX 9065A HCl hydrate DX9065A HCl hydrate DX 9065A DX-9065A DX-9065 inhibitor inhibit

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