Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0.4 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 55.00 | |
25 mg | In stock | $ 122.00 | |
50 mg | In stock | $ 228.00 | |
100 mg | In stock | $ 393.00 | |
200 mg | In stock | $ 582.00 | |
500 mg | In stock | $ 913.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | 5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0.4 nM). |
Targets&IC50 | FXa:0.7 nM |
In vitro | Rivaroxaban competitively inhibits human FXa (Ki 0.4 nM) with >10 000-fold greater selectivity than for other serine proteases; it also inhibits prothrombinase activity (IC50 2.1 nM). Rivaroxaban inhibits endogenous FXa more potently in human and rabbit plasma (IC50 21 nM) than rat plasma (IC50 290 nM). It demonstrates anticoagulant effects in human plasma, doubling prothrombin time (PT) and activates partial thromboplastin time at 0.23 and 0.69 μM, respectively [2]. |
In vivo | Rivaroxaban, administered by i.v. bolus before thrombus induction, reduces thrombus formation (ED50 0.1 mg/kg), inhibits FXa, and prolongs PT dose-dependently. PT and FXa are affected slightly at the ED50 (1.8-fold increase and 32% inhibition, respectively). At 0.3 mg/kg (dose leading to almost complete inhibition of thrombus formation), Rivaroxaban moderately prolongs PT (3.2±0.5-fold) and inhibits FXa activity (65±3%) [2]. |
Molecular Weight | 435.88 |
Formula | C19H18ClN3O5S |
CAS No. | 865479-71-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (76.47 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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5-R-Rivaroxaban 865479-71-6 Metabolism Factor Xa 5 R Rivaroxaban Fxa Inhibitor inhibit 5RRivaroxaban inhibitor