fxa — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63239	FXa-IN-1
	FXa-IN-1 is an FXa inhibitor with an IC50 value of 3 nM and a Ki value of 0.7 nM that exhibits good oral bioavailability and half-life (in vivo) and can be used to study thromboembolic diseases.
T10174	5-R-Rivaroxaban		Factor Xa
	5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0.4 nM).		Factor Xa
T4341	Betrixaban	PRT054021	Factor Xa
	Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel ...		Factor Xa
T4980	Betrixaban maleate		Factor Xa
	Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa.		Factor Xa
T0372	Gabexate mesylate	FOY	Factor Xa , Serine Protease , Proteasome
	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh...		Factor Xa , Serine Protease , Proteasome
T1184	Rivaroxaban	BAY 59-7939	Factor Xa , Thrombin
	Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both ...		Factor Xa , Thrombin
T1736	Apixaban	BMS-562247-01	Factor Xa
	Apixaban (BMS-562247-01) is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and pr...		Factor Xa
T22323	Enoxaparin sodium		Thrombin
	Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu...		Thrombin
T31206	Darexaban	YM 150,Darexaban, Tanexaban,YM150	Factor Xa
	Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...		Factor Xa
T4076	Fondaparinux sodium	Natural heparin pentasaccharide Sodium,Fondaparin sodium,SR-90107A,Arixtra	Factor Xa
	Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.		Factor Xa
T2368	Edoxaban Tosylate Monohydrate	DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban	Factor Xa , Thrombin
	Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.		Factor Xa , Thrombin
T4690	Betrixaban hydrochloride(330942-05-7(free base))	PRT054021 hydrochloride	Factor Xa
	Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).		Factor Xa
T29215	Zifaxaban	TY 602,TY602,TY-602	Factor Xa
	Zifaxaban (TY-602) is an orally active, competitive and selective inhibitor of factor Xa (FXa) with an IC50 of 11.1 nM for human FXa.Zifaxaban has a very high affinity, more than 10,000-fold higher than that of other ser...		Factor Xa
T78215	Dechloro Rivaroxaban		Factor Xa , Others
	Dechloro Rivaroxaban is an orally active and highly selective Factor Xa inhibitor.Dechloro Rivaroxaban has a significant inhibitory effect on free FXa in humans.Dechloro Rivaroxaban also has an inhibitory effect on throm...		Factor Xa , Others
T2368L	Edoxaban	Lixiana	Factor Xa , Thrombin
	Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is a...		Factor Xa , Thrombin
T77373	Concizumab	mAb 2021,NN 7415	Others
	Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, thereby blocking the interaction of this domain with the FXa active site. Injecti...		Others
T27318	Fidexaban	CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834	Factor Xa
	Fidexaban (CI1031) is a novel, potent, selective and orally active factor Xa inhibitor that has demonstrated antithrombotic activity in a variety of assays		Factor Xa
T12736	Rivaroxaban-d4	BAY 59-7939 D4	Factor Xa
	Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).		Factor Xa
T27224	DX-9065A HCl hydrate	DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065
	DX-9065A is a factor Xa inhibitor. DX-9065a inhibits proinflammatory events induced by factor Xa and gingipains. DX-9065a is a competitive inhibitor of the Spectrozyme FXa (SpFXa) cleavage by both fXa and prothrombinase ...
T16410	Otamixaban	FXV673	Others
	Otamixaban(FXV673) is an effective (Ki = 0.5 nM), selective, rapid-acting, competitive, and reversible fXa inhibitor. It also effectively inhibits both free and prothrombinase-bound fXa.		Others
T37176	Edoxaban impurity 6
	Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaba...
T70110	CVS-1578
	CVS-1578 is a potent serine protease inhibitor, targeting the S2S3 thrombin and FXa subsites.
T37175	Edoxaban impurity 4
	Edoxaban impurity 4, an impurity of Edoxaban (DU-176), is a selective, potent, and orally active inhibitor of factor Xa (FXa), exhibiting Kis of 0.561 nM for free FXa and 2.98 nM for prothrombinase. As an anticoagulant a...
T30514	BMS-344577	U259PQB19A,UNII-U259PQB19A,CHEMBL570867,BMS 344577
	BMS-344577, a lactam derivative based on arylguanidine, is a potent oral active FXA inhibitor with excellent susceptibility in vitro, good pharmacokinetics, and pharmacodynamics in animal models.
T70184	YM-60828 dihydrochloride
	YM-60828 dihydrochloride is a Factor Xa (FXa) inhibitor and anticoagulant used in the treatment of venous thromboembolic disease.
T64126	Edoxaban hydrochloride
	Edoxaban (DU-176b) hydrochloride is a potent, selective, orally active, direct inhibitor of Factor Xa (FXa), acting on human free FXa (Ki: 0.561 nM) and thrombinogenase (Ki: 2.98 nM). Edoxaban hydrochloride is more than ...
T27514	GW-813893	GW813893,GW 813893,GSK813893,GSK-813893,GSK 813893
	GW-813893 is a potent, selective and orally active factor Xa inhibitor. GW813893 inhibited FXa and prothrombinase activity with a Ki of 4.0 nM and 9.7 nM, respectively.
T76619	Methoxycarbonyl-D-Nle-Gly-Arg-pNA
	Methoxycarbonyl-D-Nle-Gly-Arg-pNA is a synthetic trypsin substrate utilized for coagulation factors IXa (FIXa) and Xa (FXa), as evidenced by studies [1] [2] [3].
T10527	Betrixaban-d6	Betrixaban D6	Others
	Betrixaban D6 is a deuterium-labeled Betrixaban. Betrixaban is a selective and orally efficacious FXa inhibitor.		Others
T19488	O-Desmethyl apixaban sulfate sodium	O-Desmethyl apixaban sulfate sodium (503612-76-8 free base)	Factor Xa
	O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM,and is a major circulating metabolite of Apixaban in humans.		Factor Xa
T12782	RWJ-445167	3DP-10017	Factor Xa , Thrombin
	RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.		Factor Xa , Thrombin
T39029	APC-6860
	APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA ve...

Compounds

FXa-IN-1

T63239

Target: Factor Xa, Serine Protease, Proteasome

Rivaroxaban

T1184

Synonym: BAY 59-7939

Target: Factor Xa, Thrombin

Apixaban

T1736

Synonym: BMS-562247-01

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Fondaparinux sodium

T4076

Synonym: Natural heparin pentasaccharide Sodium,Fondaparin sodium,SR-90107A,Arixtra

Target: Factor Xa

Edoxaban Tosylate Monohydrate

T2368

Synonym: DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban

Target: Factor Xa, Thrombin

Betrixaban hydrochloride(330942-05-7(free base))

T4690

Synonym: PRT054021 hydrochloride

Target: Factor Xa

Zifaxaban

T29215

Synonym: TY 602,TY602,TY-602

Target: Factor Xa, Others

Edoxaban

T2368L

Synonym: Lixiana

Target: Factor Xa, Thrombin

Concizumab

T77373

Synonym: mAb 2021,NN 7415

Target: Others

Fidexaban

T27318

Synonym: CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834

Target: Factor Xa

Rivaroxaban-d4

T12736

Synonym: BAY 59-7939 D4

Target: Factor Xa

DX-9065A HCl hydrate

T27224

Synonym: DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065

Synonym: U259PQB19A,UNII-U259PQB19A,CHEMBL570867,BMS 344577

Target:

YM-60828 dihydrochloride

T70184

Synonym:

Target:

Edoxaban hydrochloride

Synonym: GW813893,GW 813893,GSK813893,GSK-813893,GSK 813893

Target:

Methoxycarbonyl-D-Nle-Gly-Arg-pNA

Synonym: Betrixaban D6

Target: Others

O-Desmethyl apixaban sulfate sodium

T19488

Synonym: O-Desmethyl apixaban sulfate sodium (503612-76-8 free base)

Target: Factor Xa, Thrombin

Cat No.	Product Name	Species	Expression System
TMPY-01101	Coagulation factor X/F10 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the...

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Compounds

Recombinant Proteins

Compounds

Recombinant Proteins