fgfr2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60185	FGFR2-IN-3		FGFR
	FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].		FGFR
T61304	FGFR2-IN-1		FGFR
	FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3 with IC50s of 460, 140, and 2200 nM, respectively.FGFR2-IN-1 can be used for the study of cancers associated with FGFR2.CAS 번호13460-73-81-1		FGFR
T76672	Aprutumab	FGFR-moAb,FGFR2-TTC,BAY 1179470	FGFR
	Aprutumab (BAY 1179470) is a human FGFR2 monoclonal antibody with affinity to FGFR2 isoforms FGFR2-IIIB and FGFR2-IIIC. Aprutumab is commonly used to synthesize antibody-drug conjugates.		FGFR
T61473	FGFR2-IN-2
	FGFR2-IN-2 is a selective FGFR2 inhibitor with an IC 50 of 29 nM.
T63850	FGFR2-IN-3 hydrochloride
	FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.
T0724	Formononetin	Biochanin B,Flavosil,Formononetol	Apoptosis , FGFR
	Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.		Apoptosis , FGFR
T5122	Alofanib	RPT835	Apoptosis , FGFR
	Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR...		Apoptosis , FGFR
T37426	FIIN-1	FGFR irreversible inhibitor-1	FGFR
	FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FIIN-1 inhibited FGFR1, FGFR2,...		FGFR
T5044	Futibatinib	TAS120,FGFR-IN-1	FGFR
	Futibatinib (FGFR-IN-1) is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.		FGFR
T15185	Lucitanib	E-3810	VEGFR , FGFR
	Lucitanib (E-3810) is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively).		VEGFR , FGFR
TQ0228	Derazantinib	ARQ-087	FGFR
	Derazantinib (ARQ-087) (ARQ-087) is an ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocytes (IC50s: 4.5 nM/1.8 nM/4.5 nM).		FGFR
T6024	Zoligratinib	FF284,CH5183284,Debio 1347	FGFR
	Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively.		FGFR
T12401	Pemigatinib	INCB054828	FGFR
	Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).		FGFR
T16364	Infigratinib phosphate	NVP-BGJ398 phosphate,BGJ-398 phosphate	FGFR
	Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).		FGFR
T1895	SKLB 610		VEGFR , FGFR , PDGFR
	SKLB610, a novel multi-targeted inhibitor, inhibits angiogenesis-related tyrosine kinase VEGFR2, FGFR2, and PDGFR at a rate of 97%, 65%, and 55%, respectively, at the concentration of 10 μM in biochemical kinase assays.		VEGFR , FGFR , PDGFR
T1777	Nintedanib	BIBF 1120,Intedanib	VEGFR , FGFR , FLT , PDGFR , Src
	Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an...		VEGFR , FGFR , FLT , PDGFR , Src
T3466	FIIN-3		EGFR , FGFR
	FIIN-3 is an irreversible inhibitor of FGFR.		EGFR , FGFR
T2358	ENMD-2076		Apoptosis , VEGFR , FGFR , FLT , c-RET , PDGFR , Src , Aurora Kinase
	ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
T1948	AZD4547		VEGFR , FGFR
	AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays).		VEGFR , FGFR
T2361	LY2874455	LY 2874455,LY-2874455	VEGFR , FGFR
	LY2874455 has been used in trials studying the treatment of Advanced Cancer.		VEGFR , FGFR