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Search Results for " ffa1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T62856 FFA1 agonist-1
FFA1 agonist-1 (Compound 17a) is an orally active fatty acid receptor (FFA1) agonist (EC50: 0.75 μM).
TQ0020 AMG 837 calcium hydrate GPR
AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).
T3171 GSK137647A GSK 137647 GPR
GSK137647A (GSK 137647) is a selective FFA4 agonist.
T1781 GW9508 GW 9508 GPR , Potassium Channel
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.
T17177 TUG-424 TUG424 Others
TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).
T7127 DC260126 Apoptosis , GPR
DC260126 is a small-molecule antagonist of FFA1 (GPR40)
T22967 MEDICA16 MEDICA 16 GPR , Others , ATP Citrate Lyase
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle with an increase in insu...
T15810 LY2922470 GPR
LY2922470 reduces glucose levels along with significant enhancements in insulin and GLP-1, which is the potential for the treatment of type 2 diabetes mellitus (T2DM). LY2922470 is an effective, selective, and orally ava...
T14200 AM-1638 GPR
AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
TQ0241 TUG-770 GPR
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).
T2351 Fasiglifam TAK875 GPR
Fasiglifam (TAK875) is a potent, selective and orally bioavailable GPR40 agonist.
T62848 AMG 837 hemicalcium
AMG 837 hemicalcium is a potent, orally active GPR40/FFA1 partial agonist. AMG 837 hemicalcium inhibits the specific binding of [3H]AMG 837 to the human FFA1 receptor (pIC50: 8.13). insulin secretion and reduced glucose ...
T11583 HWL-088 Others
HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models.
T35816 ZLY032
ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and...
T15448 GW-1100 GPR
GW-1100 is a selective antagonist of GPR40 (pIC50: 6.9). GW1100 also plays the role of a GPR40 inverse agonist.
T14202 AM-4668 GPR
AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respectively.
T11459 GPR40 agonist 1 Others
GPR40 agonist 1 is an effective new GPR40 agonist (EC50s: 17 nM and 2 nM for rGPR40 and hGPR40).
T15267 GPR40 agonist 4 Others
GPR40 agonist 4 is a potent free fatty acid agonist of receptor 1 (pEC50: 7.54).
T2351L TAK-875 Hemihydrate TAK-875,Fasiglifam GPR
TAK-875 Hemihydrate (Fasiglifam) is a selective GPR40 agonist with EC50 of 14 nM, 400-fold more potent than oleic acid.
T26868 BMS-986118 BMS 986118
BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabete...
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TargetMol