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TUG-770

Name: TUG-770
Brand: TargetMol
SKU: TQ0241
Rating: 4.5 (1 reviews)

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Catalog No. TQ0241Cas No. 1402601-82-4

Alias TUG770, TUG 770

TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.

TUG-770

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Purity: 97.6%

Catalog No. TQ0241Alias TUG770, TUG 770Cas No. 1402601-82-4

TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.

Pack Size	Price	Availability
1 mg	$58	5 days
5 mg	$139	5 days
10 mg	$222	5 days
25 mg	$429	7-10 days
50 mg	$687	7-10 days
100 mg	$987	7-10 days
500 mg	$1,980	7-10 days
1 mL x 10 mM (in DMSO)	$213	5 days

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Batch Information

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Purity:97.6%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.
Targets&IC50	FFA1/GPR40 (human):6 nM (EC50)
In vitro	TUG-770 shows good stability towards human liver microsomes (HLM) and demonstrates good permeability in the Caco-2 cell assay[1].
In vivo	In C57BL/6 male mice (5-6 weeks of age) fed a 60% fat diet D12492, TUG-770 (20 mg/kg; oral administration; daily; for 28 days) significantly improved glucose tolerance[1].
Synonyms	TUG770, TUG 770

Chemical Properties

Molecular Weight	307.32
Formula	C₁₉H₁₄FNO₂
Cas No.	1402601-82-4
Smiles	OC(=O)CCc1ccc(cc1F)C#Cc1ccccc1CC#N
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 100 mg/mL (325.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2539 mL	16.2697 mL	32.5394 mL	162.6969 mL
5 mM	0.6508 mL	3.2539 mL	6.5079 mL	32.5394 mL
10 mM	0.3254 mL	1.6270 mL	3.2539 mL	16.2697 mL
20 mM	0.1627 mL	0.8135 mL	1.6270 mL	8.1348 mL
50 mM	0.0651 mL	0.3254 mL	0.6508 mL	3.2539 mL
100 mM	0.0325 mL	0.1627 mL	0.3254 mL	1.6270 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc