Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 134.00 | |
5 mg | 5 days | $ 229.00 | |
10 mg | 5 days | $ 352.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 252.00 |
Description | TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1). |
Targets&IC50 | FFA1/GPR40 (human):6 nM (EC50) |
In vitro | TUG-770 (Compound 22) displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB). TUG-770 furthermore showed excellent stability toward human liver microsomes, no inhibition of selected CYP-enzymes implicated in drug-drug interactions, no P-glycoprotein inhibition, and good permeability in the Caco-2 cell assay. |
In vivo | Examination of TUG-770 in an acute intraperitoneal glucose tolerance test (IPGTT) in normal mice revealed a good dose-dependent response with maximal reduction in glucose level reached at 50 mg/kg. The effect of TUG-770 was fully sustained after 29 days of daily oral treatment. Additional evaluation of TUG-770 in rats confirmed a significant glucose-lowering effect for the high doses already after 10 min and for all doses after 30 min. |
Molecular Weight | 307.32 |
Formula | C19H14FNO2 |
CAS No. | 1402601-82-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 100 mg/mL (325.39 mM)
You can also refer to dose conversion for different animals. More
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TUG-770 1402601-82-4 Endocrinology/Hormones GPCR/G Protein GPR TUG 770 TUG770 inhibitor inhibit