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TUG-770

Catalog No. TQ0241   CAS 1402601-82-4
Synonyms: TUG770, TUG 770

TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.

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TUG-770 Chemical Structure
TUG-770, CAS 1402601-82-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 58.00
5 mg In stock $ 139.00
10 mg In stock $ 222.00
25 mg In stock $ 429.00
50 mg In stock $ 687.00
100 mg In stock $ 987.00
500 mg In stock $ 1,980.00
1 mL * 10 mM (in DMSO) In stock $ 213.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.
Targets&IC50 FFA1/GPR40 (human):6 nM (EC50)
In vitro TUG-770 shows good stability towards human liver microsomes (HLM) and demonstrates good permeability in the Caco-2 cell assay[1].
In vivo In C57BL/6 male mice (5-6 weeks of age) fed a 60% fat diet D12492, TUG-770 (20 mg/kg; oral administration; daily; for 28 days) significantly improved glucose tolerance[1].
Synonyms TUG770, TUG 770
Molecular Weight 307.3184
Formula C19H14FNO2
CAS No. 1402601-82-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 100 mg/mL (325.39 mM)

TargetMolReferences and Literature

1. Christiansen E, et al. Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2013 May 9;4(5):441-445. 2. Christiansen E,et al. Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2013 May 9;4(5):441-445.

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Keywords

TUG-770 1402601-82-4 Endocrinology/Hormones GPCR/G Protein GPR TUG770 TUG 770 inhibitor inhibit

 

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