Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 162.00 | |
10 mg | In stock | $ 233.00 | |
25 mg | In stock | $ 389.00 | |
50 mg | In stock | $ 579.00 | |
100 mg | In stock | $ 829.00 | |
500 mg | In stock | $ 1,680.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 151.00 |
Description | TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM). |
Targets&IC50 | FFA1/GPR40:(EC50)32 nM |
In vitro | At equivalent glucose concentrations, TUG-424's roughly double enhancement of secretion in the context of 12 mM glucose parallels the effect triggered by palmitate. Increasing TUG-424 doses (100 nM to 10 µM) significantly boost glucose-stimulated insulin secretion, beginning notably at 100 nM and peaking at 3 µM. Additionally, TUG-424 slightly yet significantly diminishes basal insulin secretion at 2.8 mM glucose [1]. |
Synonyms | TUG424 |
Molecular Weight | 264.32 |
Formula | C18H16O2 |
CAS No. | 1082058-99-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (189.16 mM)
You can also refer to dose conversion for different animals. More
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TUG-424 1082058-99-8 Others TUG 424 TUG424 inhibitor inhibit