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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T39727 | ERα degrader-2 | ERK | |
ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, inhibits ERα, and has an EC50 value for estrogen receptor degradation of 0.3 nM.ERα degrader-2 can be used for the prev... | |||
T13722 | Homo-PROTAC pVHL30 degrader 1 | Others , Ligand for E3 Ligase | |
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC. | |||
T9236 | WSB1 Degrader 1 | Others , E1/E2/E3 Enzyme | |
WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects. | |||
T13721 | Homo-PROTAC cereblon degrader 1 | Others , Ligand for E3 Ligase | |
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3. | |||
T69753 | HDAC6 degrader 9c | HDAC | |
HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases. | |||
T8745 | PROTAC BRAF-V600E degrader-1 | Compound 23 | Raf |
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF. | |||
T36628 | PROTAC BRD4 Degrader-8 | PROTAC BRD4 Degrader-8 | |
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells... | |||
T40072 | PROTAC BRD4 Degrader-9 | PROTAC BRD4 Degrader-9 | |
PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate... | |||
T39902 | PROTAC IRAK4 degrader-5 | PROTAC IRAK4 degrader-5 | |
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader. | |||
T39920 | PROTAC IRAK4 degrader-3 | PROTAC IRAK4 degrader-3 | |
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau. | |||
T36242 | PROTAC BRD4 Degrader-5 | PROTAC BRD4 Degrader-5 | |
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1]. | |||
T39903 | PROTAC IRAK4 degrader-6 | PROTAC IRAK4 degrader-6 | |
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T40074 | PROTAC BRD4 Degrader-15 | PROTAC BRD4 Degrader-15 | |
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BR... | |||
T4207 | (S,R,S)-AHPC hydrochloride | VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). | |||
T40073 | PROTAC BRD4 Degrader-10 | PROTAC BRD4 Degrader-10 | |
PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 ca... | |||
T37329 | PROTAC IDO1 Degrader-1 | PROTAC IDO1 Degrader-1 | |
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the... | |||
T39901 | PROTAC IRAK4 degrader-4 | PROTAC IRAK4 degrader-4 | |
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T40250 | SHP2 protein degrader-1 | SHP2 protein degrader-1 | |
SHP2 protein degrader-1 is a highly efficient allosteric inhibitor targeting SHP2. It effectively induces degradation of SHP2 protein, resulting in cell apoptosis. This compound shows promising potential for studying dis... | |||
T39996 | PROTAC CDK9 degrader-4 | PROTAC CDK9 degrader-4 | |
PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9... | |||
T40075 | PROTAC BRD4 Degrader-13 | PROTAC BRD4 Degrader-13 | |
PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cel... |