ckd — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27033	CKD-712	CKD 712,CKD712
	CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by s...
T7551	Belotecan hydrochloride	CKD-602	Topoisomerase
	Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity		Topoisomerase
T13278	Valecobulin hydrochloride	CKD-516 hydrochloride	Microtubule Associated
	Valecobulin hydrochloride (CKD-516 hydrochloride) is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.		Microtubule Associated
T27841	Lobeglitazone Sulfate	CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang	NOD
	Lobeglitazone Sulfate（CKD-501 Sulfate） is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2...		NOD
T36700	CKD 602
	Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian ...
T14976	CKD-519		Others
	CKD-519 is a selective inhibitor of cholesteryl ester transfer protein (CETP). It inhibits CETP-mediated transfer of cholesteryl ester in human serum (IC50: 2.3 nM).		Others
T13278L	Valecobulin	CKD-516	Others
	Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.		Others
T28945	Tenofovir disoproxil aspartate	CKD-390,CKD390,CKD 390
	Tenofovir disoproxil aspartate, a nucleotide reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection.
T19871	Beloranib	CKD-732,ZGN 440
	Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.
T69011	Lobeglitazone
	Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat ce...
T8494	NS-3-008 hydrochloride	NS-3-008 HCl	Others
	NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).		Others
T16708	R-268712		ALK , TGF-beta/Smad
	R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.		ALK , TGF-beta/Smad
T71845	Lockdown
	Lockdown is a reversible and non-competitive PPM1F inhibitor. Lockdown is selective for PPM1F, because this compound does not inhibit other protein phosphatases in vitro and does not induce additional phenotypes in PPM1F...
T8181	Poricoic acid A	Poricoic acid A(F)	Others
	Poricoic acid A (Poricoic acid A(F)) is a natural product with antitumor activity. It also enhances melatonin inhibition of AKI-to-CKD transition by regulating the Gas6/AxlNFκB/Nrf2 axis.		Others
T21977	P-Cresyl sulfate		Others
	p-Cresyl Sulfate is a major uremic toxin found in the blood of patients with chronic kidney disease (CKD), derived from the metabolites of tyrosine and phenylalanine in the liver.		Others
T30479	Bis-T-23	Bis T-23,Bis-T 23,AG1717	HIV Protease
	Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV...		HIV Protease
T13604	CDDO-dhTFEA		Others , NF-κB , Nrf2
	CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi...		Others , NF-κB , Nrf2
T12823	S516		Microtubule Associated
	S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.		Microtubule Associated
T39410	Zevaquenabant	(S)-MRI-1867
	Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD)...
T69294	UK‑396082
	UK-396082 is a potent inhibitor of thrombin-activated fibrinolytic inhibitor (TAFI), enhancing plasmin activity while concurrently reducing levels of the extracellular matrix (ECM). This compound is valuable for research...