Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
2 mg | In stock | $ 93.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 268.00 | |
25 mg | In stock | $ 538.00 | |
50 mg | In stock | $ 777.00 | |
100 mg | In stock | $ 1,090.00 | |
500 mg | In stock | $ 2,170.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 197.00 |
Description | CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD). |
In vivo | CDDO-dhTFEA restores hypertension, increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis, and inflammation in the chronic kidney disease rats [2]. |
Molecular Weight | 574.72 |
Formula | C33H45F3N2O3 |
CAS No. | 1191265-33-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (174.00 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CDDO-dhTFEA 1191265-33-4 Immunology/Inflammation NF-Κb Others Nrf2 NF-κB RTA dh 404 Nuclear factor-κB Inhibitor RTA dh-404 CDDOdhTFEA Keap1-Nrf2 RTA dh404 Nuclear factor-kappaB CDDO dhTFEA inhibit inhibitor