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Bis-T-23

Catalog No. T30479 CAS 171674-76-3

Synonyms: Bis T-23, Bis-T 23, AG1717

Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).

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Bis-T-23, CAS 171674-76-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 98.77%

Purity: 96.81%

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Chemical Properties

Storage & Solubility Information

Description	Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).
In vitro	Bis-T-23 (AG1717) (0.18 μM) inhibits HIV-1 integrase.[5] AG1717 (2 μM) inhibits the binding of integrase to substrate DNA.[5]
In vivo	Bis-T-23 (1 ng) targets actin-dependent kinesin oligomerization in podocytes to promote normal GFB function.[6] Bis-T-23 (i.p. ; 20, 40 mg/kg) improves proteinuria by altering actin kinetics.[6] Bis-T-23 (i.p. ; 20, 40 mg/kg) ameliorates or prevents proteinuria and reduces thylakoid matrix expansion in various genetic and chronic glomerular disease models in rodents.[6]

Synonyms	Bis T-23, Bis-T 23, AG1717
Molecular Weight	480.43
Formula	C23H20N4O8
CAS No.	171674-76-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 12.01 mg/ml (25 mM)

References and Literature

1. Sever S, Schiffer M. Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases. Kidney Int. 2018 Jun ; 93(6):1298-1307. doi: 10.1016/j.kint.2017.12.028. Epub 2018 Apr 17. Review. PubMed PMID: 29678354 ; PubMed Central PMCID: PMC5967993. 2. Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H. O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes. Nephrol Dial Transplant. 2017 Sep 1 ; 32(9):1477-1487. doi: 10.1093/ndt/gfw463. PubMed PMID: 28339907. 3. Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, Sever S. Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation. J Am Soc Nephrol. 2017 Feb ; 28(2):446-451. doi: 10.1681/ASN.2016010008. Epub 2016 Jul 18. PubMed PMID: 27432739 ; PubMed Central PMCID: PMC5280009. 4. Del Nogal-Avila M, Donoro-Blazquez H, Saha MK, Marshall CB, Clement LC, Macé CE, Chugh SS. Novel therapeutic approaches for chronic kidney disease due to glomerular disorders. Am J Physiol Renal Physiol. 2016 Jul 1 ; 311(1):F63-5. doi: 10.1152/ajprenal.00245.2016. Epub 2016 May Review. PubMed PMID: 27147672 ; PubMed Central PMCID: PMC4967169. 5. Mazumder A, et al. Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase. Biochemistry. 1995 Nov 21;34(46):15111-22. 6. Schiffer M, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015 ; 21(6):601-609.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Anti-Viral Compound Library Bioactive Compounds Library Max

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Keywords

Bis-T-23 171674-76-3 Microbiology/Virology Proteases/Proteasome HIV Protease Bis T-23 AG-1717 Bis-T 23 AG 1717 AG1717 inhibitor inhibit

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