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Cat No. | Product Name | Synonyms | Targets |
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T4428 | CCT241736 | FLT , Aurora Kinase | |
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica... | |||
T9638 | CCT241161 | Raf | |
CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It displays significant activity against BRAF and NRAS mutant melanomas... | |||
T7080 | CCT245737 | SRA737 | Chk |
CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM). | |||
T14907 | CCT251545 | Wnt/beta-catenin | |
CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells). | |||
T10718L | CCT241533 hydrochloride | Chk | |
CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM). | |||
T14904 | CCT244747 | Chk | |
CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM). | |||
T36704 | CCT241533 dihydrochloride | CCT 241533 dihydrochloride | |
Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radi... | |||
T10718 | CCT241533 | Chk | |
CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM). | |||
T22633 | CCT251545 analogue, Compound 51 | Others | |
CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. ... | |||
T62775 | CCT245232 | ||
CCT245232 is a potent inhibitor of heat-stimulated factor 1 (HSF1). CCT245232 has the potential to be used in studies of proliferative diseases such as cancer. | |||
T14906 | CCT251455 | Kinesin | |
CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM). | |||
T71353 | CCT239065 | ||
CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor. | |||
T70553 | CCT245737(S) | ||
CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor. | |||
T14905 | CCT251236 | HSP | |
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 induction (IC50: 19 nM). |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02183 | CCT2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating t... |