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CCT251455

Catalog No. T14906   CAS 1400284-80-1

CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).

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CCT251455 Chemical Structure
CCT251455, CAS 1400284-80-1
Pack Size Availability Price/USD Quantity
25 mg 8-10 weeks $ 1,820.00
50 mg 8-10 weeks $ 2,380.00
100 mg 8-10 weeks $ 3,100.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
Targets&IC50 Mps1:3 nM
In vitro CCT251455 is a highly potent inhibitor of MPS1 that demonstrates high selectivity versus kinases tested in a broad kinome profiling panel. CCT251455 inhibits P-MPS1 (IC50: 0.04 μM in the cell-based assay; GI50: 0.16 μM).
In vivo CCT251455 demonstrates a good oral pharmacokinetic profile in mice and rats as well as inhibition of MPS1 activity in vivo following oral administration.
Molecular Weight 503.98
Formula C26H26ClN7O2
CAS No. 1400284-80-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Naud S, et al. Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem. 2013 Dec 27;56(24):10045-65.

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Keywords

CCT251455 1400284-80-1 Cytoskeletal Signaling Kinesin CCT-251455 CCT 251455 inhibitor inhibit

 

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