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Search Results for " bcr-fms "

5

Compounds

Cat No.	Product Name	Synonyms	Targets
T2341	KW-2449	KW2449	Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase
	KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
T2640	Rebastinib	DCC2036,DCC 2036,DCC-2036	Apoptosis , FLT , Bcr-Abl , Src
	DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re...		Apoptosis , FLT , Bcr-Abl , Src
T3068	AT9283	J-504568	Apoptosis , FLT , JAK , Bcr-Abl , Aurora Kinase , Autophagy
	AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).		Apoptosis , FLT , JAK , Bcr-Abl , Aurora Kinase , Autophagy
T4053	AST 487	NVP-AST 487	VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
	AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.		VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
T1925	PLX647		c-Fms , c-Kit
	PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).		c-Fms , c-Kit

Compounds

Synonym: KW2449

Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

Synonym: J-504568

Target: Apoptosis, FLT, JAK, Bcr-Abl, Aurora Kinase, Autophagy

Synonym: NVP-AST 487

Target: VEGFR, FLT, c-RET, Bcr-Abl, c-Kit

Target: c-Fms, c-Kit

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