bace1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39484	BACE1-IN-6	BACE1-IN-6
	BACE1-IN-6 is a BACE1 inhibitor with an IC 50 value of 1.5 nM.
T10451	BACE1-IN-2		BACE
	BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).		BACE
T10450	BACE1-IN-1		BACE
	BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).		BACE
T10453	BACE1-IN-5		Beta Amyloid , BACE
	BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM aga...		Beta Amyloid , BACE
T10452	BACE1-IN-4		BACE
	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.		BACE
T73076	BACE1-IN-10		Beta-Secretase
	BACE1-IN-10 is a potent inhibitor of BACE1, demonstrating sub-micromolar activity against recombinant BACE1 (rBACE1) [1].		Beta-Secretase
T64074	BACE1-IN-8
	BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).
T63867	BACE1-IN-12
	BACE1-IN-12 is a potent BACE1 inhibitor (IC50: 8.9 μM) that can cross the blood-brain barrier. BACE1-IN-12 selectively inhibits BuChE (butylcholinesterase) activity (IC50: 3.2 μM). BACE1-IN-12 has potential for anti-Alzh...
T79022	BACE1-IN-13		Beta-Secretase
	BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM). It is considered safe for the cardiovascular ...		Beta-Secretase
T61956	BACE1/2-IN-1
	BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BA...
T62719	AChE/BACE1/GSK3β-IN-1
	AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD).
T6058	LY2886721		Beta-Secretase , BACE
	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.		Beta-Secretase , BACE
T7011	Verubecestat	MK-8931	Beta-Secretase , BACE
	Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.		Beta-Secretase , BACE
T10449	BACE-1 inhibitor 1		Others
	BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM).		Others
TQ0238	Lanabecestat	LY3314814,AZD3293	BACE
	Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier, Lanabecestat can be used for the study of neurological diseases like Alzhei...		BACE
T12188	NB-360		BACE
	NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat...		BACE
T2639	LY2811376		Beta Amyloid , Beta-Secretase , BACE
	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...		Beta Amyloid , Beta-Secretase , BACE
TN1472	Cassiaside		Beta-Secretase , BACE
	Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galactosamine injury and has potential anti-Alzheimer's disease (...		Beta-Secretase , BACE
T6772	AZD3839 free base	AZD3839	Beta-Secretase , BACE
	AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.		Beta-Secretase , BACE
T4398	LX2343		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.		Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy