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BACE1-IN-4

Catalog No. T10452 CAS 2361157-92-6

BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.

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BACE1-IN-4, CAS 2361157-92-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
Targets&IC50	BACE2:1740 nM , BACE2:2090 nM , BACE1:(ki)1.9 nM , BACE1:3.8 nM
In vitro	BACE1-IN-4 (Compound 22) is a BACE1 inhibitor, more selective at BACE1 over BACE2 (IC50, 2090 nM; Ki, 1740 nM).

Molecular Weight	511.57
Formula	C21H23F2N5O4S2
CAS No.	2361157-92-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fujimoto K, et al. Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. J Med Chem. 2019 May 23;62(10):5080-5095.

Related Products

Related compounds with same targets

Lanabecestat Putraflavone Kushenol C Anatabine Bavachromene Epiberberine chloride PF-06751979 BACE1-IN-5

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BACE1-IN-4 2361157-92-6 神经科学 BACE BACE-1-IN-4 BACE1 IN 4 BACE1IN4 Inhibitor inhibitor inhibit

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