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BACE1-IN-4
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Catalog No. T10452Cas No. 2361157-92-6
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), exhibiting greater selectivity for BACE1 over BACE2.
BACE1-IN-4
😃Good
Catalog No. T10452Cas No. 2361157-92-6
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), exhibiting greater selectivity for BACE1 over BACE2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $3,270 | 3-6 months | |
| 50 mg | $4,080 | 3-6 months | |
| 100 mg | $5,300 | 3-6 months |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), exhibiting greater selectivity for BACE1 over BACE2. |
| Targets&IC50 | BACE2:1740 nM , BACE1:(ki)1.9 nM , BACE2:2090 nM , BACE1:3.8 nM |
| In vitro | BACE1-IN-4 (Compound 22) is a selective BACE1 inhibitor with an IC50 of 2090 nM and a Ki of 1740 nM, demonstrating greater selectivity for BACE1 over BACE2. |
| Molecular Weight | 511.57 |
| Formula | C21H23F2N5O4S2 |
| Cas No. | 2361157-92-6 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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