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Lanabecestat

Lanabecestat
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Purity:98.55%
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Lanabecestat

Catalog No. TQ0238Cas No. 1383982-64-6
Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier, Lanabecestat can be used for the study of neurological diseases like Alzheimer's disease.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePrice/USDAvailabilityQuantity
1 mg$149In Stock
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Product Introduction

Bioactivity
Description
Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier, Lanabecestat can be used for the study of neurological diseases like Alzheimer's disease.
In vitro
Lanabecestat differentially altered the protein levels of microglia in 5xFAD and APP KI mice[1].
In vivo
Lanabecestat treatment (1 mg/kg; oral gavage; once daily; for 3 weeks) increased the bursting frequency in 4-AP-induced cell models in Bace1-null mice[1].
Cell Research
Cells are incubated with different Lanabecestat concentrations for 5 to 16?h, and the release of sAβPPβ, Aβ1-40, Aβ1-42, or sAβPPα into the medium is analyzed using kits. Cytotoxic effect of Lanabecestat is evaluated in the cell plates using cell proliferation/cytotoxicity kit.
Animal Research
Female 7- to 14-week-old C57BL/6 mice (n=6 per treatment group and time point) receive a vehicle or Lanabecestat solution at 50, 100, or 200 μmol/kg (20, 41, or 82?mg/kg) as a single dose via oral gavage. Mice and guinea pigs are anesthetized 1.5, 2, 3, 4, 6, 8, 16, 24, or 48?h after the (last) administration of vehicle or drug and are then kept under isoflurane anesthesia. Cerebrospinal fluid (CSF) is aspirated from the cisterna magna, and plasma is isolated from blood collected by cardiac puncture into EDTA tubes. The animals are then sacrificed by decapitation, and the brains are dissected into hemispheres.
AliasLY3314814, AZD3293
Chemical Properties
Molecular Weight412.53
FormulaC26H28N4O
Cas No.1383982-64-6
Storage & Solubility Information
Storagestore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 80 mg/mL (193.92 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4241 mL12.1203 mL24.2407 mL121.2033 mL
5 mM0.4848 mL2.4241 mL4.8481 mL24.2407 mL
10 mM0.2424 mL1.2120 mL2.4241 mL12.1203 mL
20 mM0.1212 mL0.6060 mL1.2120 mL6.0602 mL
50 mM0.0485 mL0.2424 mL0.4848 mL2.4241 mL
100 mM0.0242 mL0.1212 mL0.2424 mL1.2120 mL

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