aβ-like — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid	Compound W	Gamma-secretase
	3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).		Gamma-secretase
TMS1461	Qingyangshengenin B	Otophylloside B	Beta Amyloid
	Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mR...		Beta Amyloid
T4364	Aftin-4	Aftin 4,Aftin4	Beta Amyloid , Gamma-secretase
	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...		Beta Amyloid , Gamma-secretase
T32614	L-Clausenamide	(-)-Clausenamide	Microtubule Associated
	L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents t...		Microtubule Associated
T2777	Ginsenoside Rg1	Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,Panaxoside A,Ginsenoside A2	Apoptosis , Beta Amyloid , NF-κB
	Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level i...		Apoptosis , Beta Amyloid , NF-κB
T4956	Tetrahydroxystilbene-2-O-β-D-glucoside	tetrahydroxyl diphenylethylene-2-o-gluco,EH-201	Others
	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc...		Others
T61050	BChE-IN-7
	BChE-IN-7 (compound 13) is a potent, selective, and reversible inhibitor of AChE and BChE. The IC50 value of BChE-IN-7 for BChE is 0.06 μM. BChE-IN-7 is able to cross the blood-brain barrier and protect neuronal-like cel...
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42)), a significant component of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, results from the alpha- and gamma-secretase cleavage of amyloid precursor protei...
TN3410	Anatabine		Beta Amyloid , IL Receptor , TNF , NF-κB , BACE , COX , STAT
	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects, it inhibits BACE-1 transcription and r...
T76022	Chemerin-9 (149-157) (TFA)
	Chemerin-9 (149-157) TFA is a potent CMKLR1 (chemokine-like receptor 1) agonist with anti-inflammatory properties. It activates phosphorylation of Akt and ERK and induces ROS production, beneficially modulating immune re...