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Search Result

Search Results for " apelin "

Targets

Apelin receptor Apelin receptor

41

Compounds

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
TP1260 [Pyr1]-Apelin-13 [pGlu1]-Apelin-13 Apelin receptor
[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist.
T39823L Apelin-12 acetate Apelin-12 acetate (229961-08-4 Free base) Apelin receptor , p38 MAPK , JNK
Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons.
TP2092L Apelin-17 (human, bovine) acetate Apelin-17 (human, bovine) acetate(217082-57-0 free base) HIV Protease
Apelin-17 (human, bovine) acetate is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).
T7656 Apelin-13
Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ...
T7847 Apelin-13 triTFA(217082-58-1(free base)) Others
Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.
TP2093 Apelin-36(human) Apelin-36 (human)
Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, ...
T35374 (Ala13)-Apelin-13 (Ala13)-Apelin-13 Others
(Ala13)-Apelin-13 is a useful organic compound for research related to life sciences. The catalog number is T35374 and the CAS number is 568565-11-7.
TP2092 Apelin-17(human, bovine) Apelin-17 (human, bovine)
Endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).
TP2094 Apelin-36(rat, mouse) Apelin-36 (rat, mouse)
Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiov...
T39823 Apelin-12
Apelin-12 is a highly potent C-terminal fragment of a polypeptide that exhibits a strong affinity towards the orphan receptor APJ. It plays a role in maintaining body fluid balance and regulating feeding control in the c...
T10346 Apelin agonist 1 Others
Apelin agonist 1 is an oral selective apelin agonist AM-2995, an agonist of the APJ (APLNR, angiotensin receptor like-1) receptor. It may be used in the treatment of cardiovascular conditions.
TP1424 Apelin-13 TFA (217082-58-1 free base) Apelin-13 TFA
Apelin-13 is an endogenous ligand of APJ receptor, and the EC 50 value of activated G protein coupled receptor is 0.37 nM.
T35374L (Ala13)-Apelin-13 acetate Apelin receptor
(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.
T26630 Ani9 Ani 9,Ani-9,Apelin-12 acetate (229961-08-4 Free base) Chloride channel
Ani9 is a high selective blocker of Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) with an IC50 of 77 nM and can be used in studies about ANO1 and the treatment of ancer, hypertension, pain, diarrhea and asthma.
T75783 Apelin-36(human) TFA
Apelin-36(human) TFA, an endogenous agonist of the orphan G protein-coupled receptor APJ, exhibits a potent EC50 of 20 nM and high affinity (pIC5 50 = 8.61) for human APJ receptors in HEK 293 cells. It is involved in sig...
T78109 (Ala13)-Apelin-13 TFA
'(Ala13)-Apelin-13 TFA acts as a potent antagonist of the apelin receptors (APJ) and impedes gastric motility via the vagal cholinergic pathway [1].'
T75785 Apelin-17(human, bovine) TFA
Apelin-17(human, bovine) TFA is an endogenous agonist of the orphan G protein-coupled receptor APJ. This compound demonstrates affinity for human APJ receptors on HEK 293 cells, evidenced by a pIC50 value of 9.02. Additi...
T75784 Apelin-36(rat, mouse) TFA
Apelin-36(rat, mouse) TFA, an endogenous agonist for the orphan G protein-coupled receptor APJ, exhibits a strong affinity for APJ receptors with an IC 50 of 5.4 nM and effectively inhibits cAMP production with an EC 50 ...
T34516 Sapelin B NSC 270047,NSC270047,NSC-270047
Sapelin B is a triterpenoid.
T34515 Sapelin A NSC-270046,NSC 270046,NSC270046
Sapelin A is a terpenoid.
T10843 CMF019 Apelin receptor
CMF019 is a potent agonist of the Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ (pKis: 8.58, 8.49, and 8.71 for the human, rat, and mouse).
T14390L (2R,3S)-Azelaprag Apelin receptor
(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 µM.(2R,3S)-N-(4-(...
T4390 ML221 Apelin receptor , Arrestin
ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
T14390 Azelaprag AMG 986 Apelin receptor
Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.
TP1922L1 ELA-11 (human) acetate(1784687-32-6 free base) Apelin receptor , Arrestin
ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
T9721 ML339 CXCR
ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
TP2001 MM 54
Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens surviv...
T63669 APJ receptor agonist 6
APJ receptor agonist 6 is a potent agonist of the APJ (apelin receptor) (Ki: 0.059 μM). (EC50: 6.22 μM).
T61330 ML233
ML233 is a potent non-peptide apelin receptor agonist (EC50 = 3.7 μM) that exhibits more than 21-fold selectivity over the closely related angiotensin 1 receptor (AT1) (>79 μM) [1].
TP2096 ELA-21 (human)
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh...
T64305 APJ receptor agonist 7
APJ receptor agonist 7 (compound 37) is an orally active APJ (apelin receptor) agonist (Ki: 0.059 μM). arrestin (EC50: 0.063 μM).
TP1922 ELA-11(human) ELA-11 (human)
High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
TP1923 Elabela(19-32) ELA-14 (human)
Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.
T63153 APJ receptor agonist 5
APJ receptor agonist 5 (compound 3) is a potent and orally active apelin receptor (APJ) agonist (EC 50:0.4 nM). APJ receptor agonist 5 has excellent pharmacokinetic profiles in rodent models of heart failure (HF) and an ...
T39587 APJ receptor agonist 4
APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models an...
TP2000 MM 07
Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in...
T76044 Elabela(19-32) TFA
Elabela(19-32) TFA, an effective fragment of ELABELA (ELA), selectively engages with the apelin receptor (APJ). This compound initiates G αi1 and β-arrestin-2 signaling, demonstrating EC50 values of 8.6 nM and 166 nM, re...
T39813 APJ receptor agonist 1
APJ receptor agonist 1, a potent biphenyl acid derivative, acts as an agonist (EC50 of 0.093 nM and 0.12 nM for human and rat APJ receptors, respectively) for the APJ receptor (APJ-R). It exhibits significant in vitro po...
T76053 ELA-11(human) TFA
ELA-11(human) TFA, a bioactive fragment of ELA-32, acts as a high-affinity apelin receptor agonist (K i =14 nM). It effectively inhibits forskolin-induced cAMP production and promotes β-arrestin recruitment in vitro, hig...
TP2097 ELA-32(human) ELA-32 (human)
Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein ...
T76052 ELA-32(human) TFA
ELA-32(human) TFA is a potent apelin receptor agonist with high affinity, demonstrating an IC50 of 0.27 nM and a Kd of 0.51 nM. This compound does not bind to GPR15 or GPR25. It activates the PI3K/AKT signaling pathway, ...

Compounds

[Pyr1]-Apelin-13
TP1260
Synonym: [pGlu1]-Apelin-13
Target: Apelin receptor
Apelin-12 acetate
T39823L
Synonym: Apelin-12 acetate (229961-08-4 Free base)
Target: Apelin receptor, p38 MAPK, JNK
Apelin-17 (human, bovine) acetate
TP2092L
Synonym: Apelin-17 (human, bovine) acetate(217082-57-0 free base)
Target: HIV Protease
Apelin-13
T7656
Synonym:
Target:
Apelin-13 triTFA(217082-58-1(free base))
T7847
Synonym:
Target: Others
Apelin-36(human)
TP2093
Synonym: Apelin-36 (human)
Target:
(Ala13)-Apelin-13
T35374
Synonym: (Ala13)-Apelin-13
Target: Others
Apelin-17(human, bovine)
TP2092
Synonym: Apelin-17 (human, bovine)
Target:
Apelin-36(rat, mouse)
TP2094
Synonym: Apelin-36 (rat, mouse)
Target:
Apelin-12
T39823
Synonym:
Target:
Apelin agonist 1
T10346
Synonym:
Target: Others
Apelin-13 TFA (217082-58-1 free base)
TP1424
Synonym: Apelin-13 TFA
Target:
(Ala13)-Apelin-13 acetate
T35374L
Synonym:
Target: Apelin receptor
Ani9
T26630
Synonym: Ani 9,Ani-9,Apelin-12 acetate (229961-08-4 Free base)
Target: Chloride channel
Apelin-36(human) TFA
T75783
Synonym:
Target:
(Ala13)-Apelin-13 TFA
T78109
Synonym:
Target:
Apelin-17(human, bovine) TFA
T75785
Synonym:
Target:
Apelin-36(rat, mouse) TFA
T75784
Synonym:
Target:
Sapelin B
T34516
Synonym: NSC 270047,NSC270047,NSC-270047
Target:
Sapelin A
T34515
Synonym: NSC-270046,NSC 270046,NSC270046
Target:
CMF019
T10843
Synonym:
Target: Apelin receptor
(2R,3S)-Azelaprag
T14390L
Synonym:
Target: Apelin receptor
ML221
T4390
Synonym:
Target: Apelin receptor, Arrestin
Azelaprag
T14390
Synonym: AMG 986
Target: Apelin receptor
ELA-11 (human) acetate(1784687-32-6 free base)
TP1922L1
Synonym:
Target: Apelin receptor, Arrestin
ML339
T9721
Synonym:
Target: CXCR
MM 54
TP2001
Synonym:
Target:
APJ receptor agonist 6
T63669
Synonym:
Target:
ML233
T61330
Synonym:
Target:
ELA-21 (human)
TP2096
Synonym:
Target:
APJ receptor agonist 7
T64305
Synonym:
Target:
ELA-11(human)
TP1922
Synonym: ELA-11 (human)
Target:
Elabela(19-32)
TP1923
Synonym: ELA-14 (human)
Target:
APJ receptor agonist 5
T63153
Synonym:
Target:
APJ receptor agonist 4
T39587
Synonym:
Target:
MM 07
TP2000
Synonym:
Target:
Elabela(19-32) TFA
T76044
Synonym:
Target:
APJ receptor agonist 1
T39813
Synonym:
Target:
ELA-11(human) TFA
T76053
Synonym:
Target:
ELA-32(human)
TP2097
Synonym: ELA-32 (human)
Target:
ELA-32(human) TFA
T76052
Synonym:
Target:

Recombinant Proteins

Species：
Human (2)
Mouse (2)
Expression System：
HEK293 (3)
Human Cells (1)
Tag：
C-hFc (2)
C-Avi-6His (1)
C-hFc-Avi (1)
Cat No. Product Name Species Expression System
TMPK-01222 APLN Protein, Mouse, Recombinant (hFc) Mouse HEK293
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized...
TMPK-01221 APLN Protein, Mouse, Recombinant (hFc & Avi), Biotinylated Mouse HEK293
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized...
TMPK-01236 APLN Protein, Human, Recombinant (hFc) Human HEK293
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized...
TMPJ-00386 ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated Human Human Cells
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypept...
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