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ML339

Catalog No. T9721 CAS 2579689-83-9

ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.

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ML339, CAS 2579689-83-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
Targets&IC50	CXCR6:140 nM
In vitro	The murine assay was validated using anti-mCXCR16 as an antagonist positive control tested in the presence of an EC80 concentration of mCXCL16 (IC50 = 1.5 nM; % response = 100%). Probe ML339 was shown to be 100-fold less active at the murine CXCR6 receptor using the DiscoveRx β-arrestin cell-based assay format[1].

Molecular Weight	502
Formula	C26H32ClN3O5
CAS No.	2579689-83-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (249.00 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Paul M. Hershberger, et al. Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ML339 2579689-83-9 Autophagy GPCR/G Protein Immunology/Inflammation CXCR prostate cancer CXC chemokine receptors inhibit CXCR6 ML 339 Inhibitor ML-339 inhibitor

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