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Search Results for " ape1 "

8

Compounds

Cat No. Product Name Synonyms Targets
T61487 APE1-IN-1 DNA/RNA Synthesis
APE1-IN-1 is a potent purine/pyrimidine endonuclease 1 (APE1)-free inhibitor that crosses the blood-brain barrier with potential antitumor activity and potentiates the cytotoxicity of the alkylating agent, methyl methane...
T73299 APE1-IN-2 Apoptosis
APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Exhibiting anticancer properties, APE1-IN-2 prompts the intracellul...
T15507 Hycanthone Etrenol(mesylate),Win 249-33 DNA/RNA Synthesis , Topoisomerase , Parasite
Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibit...
T6823 E3330 HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T6456 CRT0044876 NSC 69877,7-NO2-ICA,NSC 69877,7-Nitroindole-2-Carboxylic Acid DNA/RNA Synthesis
CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
T26396 6-Hydroxy-DOPA 6-Hydroxy-DL-DOPA DNA/RNA Synthesis
6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
T66154 Paroxypropione
It is an inhibitor of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)
T70733 APX2009
APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell prolifer...
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