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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T61487 | APE1-IN-1 | DNA/RNA Synthesis | |
APE1-IN-1 is a potent purine/pyrimidine endonuclease 1 (APE1)-free inhibitor that crosses the blood-brain barrier with potential antitumor activity and potentiates the cytotoxicity of the alkylating agent, methyl methane... | |||
T73299 | APE1-IN-2 | Apoptosis | |
APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Exhibiting anticancer properties, APE1-IN-2 prompts the intracellul... | |||
T15507 | Hycanthone | Etrenol(mesylate),Win 249-33 | DNA/RNA Synthesis , Topoisomerase , Parasite |
Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibit... | |||
T6823 | E3330 | HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis | |
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. | |||
T6456 | CRT0044876 | NSC 69877,7-NO2-ICA,NSC 69877,7-Nitroindole-2-Carboxylic Acid | DNA/RNA Synthesis |
CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM. | |||
T26396 | 6-Hydroxy-DOPA | 6-Hydroxy-DL-DOPA | DNA/RNA Synthesis |
6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1. | |||
T66154 | Paroxypropione | ||
It is an inhibitor of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) | |||
T70733 | APX2009 | ||
APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell prolifer... |