Co-inhibitory Immune Checkpoint Proteins

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

Cat No.	product name / Synonyms	Species	Expression System
TMPJ-01247	BTN2A2 Protein, Human, Recombinant (hFc) BTN2A2 Protein, Human, Recombinant (hFc)	Human	Human Cells
TMPJ-01247	Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyro...
TMPJ-01421	LAG-3 Protein, Cynomolgus, Recombinant (hFc) LAG-3 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	Human Cells
TMPJ-01421	Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene co...
TMPJ-01455	Galectin-9 Protein, Human, Recombinant (His) Galectin-9 Protein, Human, Recombinant (His)	Human	Human Cells
TMPJ-01455	Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galect...
TMPK-00062	CD160 Protein, Human, Recombinant (His & Avi) CD160 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00062	CD160 (also Natural killer cell receptor BY55) is a 27 ‑ 30 kDa member of the Ig superfamily. In human, it is expressed principally on nonmyeloid hematopoietic c...
TMPK-00112	CTLA-4 Protein, Human, Recombinant (His & Avi), Biotinylated CTLA-4 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00112	CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune ...
TMPK-00166	PD-L2 Protein, Human, Recombinant (His & Avi) PD-L2 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00166	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T...
TMPK-00172	B7-H4 Protein, Human, Recombinant (His & Avi) B7-H4 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00172	B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas i...
TMPK-00177	LAIR1 Protein, Human, Recombinant (His & Avi) LAIR1 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00177	LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig sup...
TMPK-00178	B7-1 Protein, Human, Recombinant (His & Avi) B7-1 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00178	Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal ne...
TMPK-00179	B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated	Human	HEK293
TMPK-00179	Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal ne...
TMPK-00180	PD-1 Protein, Human, Recombinant (aa 25-167, hFc & Avi), Biotinylated PD-1 Protein, Human, Recombinant (aa 25-167, hFc & Avi), Biotinylated	Human	HEK293
TMPK-00180	Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's resp...
TMPK-00181	PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated	Mouse	HEK293
TMPK-00181	Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's resp...
TMPK-00182	PD-L1 Protein, Human, Recombinant (aa 19-238, His & Avi), Biotinylated PD-L1 Protein, Human, Recombinant (aa 19-238, His & Avi), Biotinylated	Human	HEK293
TMPK-00182	B7-H1, also known as PD-L1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 has been ident...
TMPK-00186	CD300A Protein, Human, Recombinant (Avi) CD300A Protein, Human, Recombinant (Avi)	Human	HEK293
TMPK-00186	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
TMPK-00187	CD300A Protein, Human, Recombinant (Avi), Biotinylated CD300A Protein, Human, Recombinant (Avi), Biotinylated	Human	HEK293
TMPK-00187	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
TMPK-00189	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His & Avi), Biotinylated TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00189	Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded...
TMPK-00190	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (aa 22-200, His) TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (aa 22-200, His)	Human	HEK293
TMPK-00190	Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded...
TMPK-00204	FGL1 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated FGL1 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293
TMPK-00204	Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene.Fibrinogen-like protein 1...
TMPK-00212	CD300A Protein, Mouse, Recombinant (His) CD300A Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPK-00212	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
TMPK-00222	SLAMF6 Protein, Human, Recombinant (His & Avi) SLAMF6 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00222	SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobul...