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Co-inhibitory Immune Checkpoint Proteins

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

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Species
Canine (8)
Cavia porcellus (1)
Cynomolgus (60)
Human (196)
Marmoset (1)
Mouse (80)
Rabbit (2)
Rat (25)
Rhesus (33)
Expression System
Baculovirus Insect Cells (5)
CHO Cells (1)
E. coli (5)
HEK293 Cells (380)
P. pastoris (Yeast) (1)
Tag
Avi (34)
C-6xHis (25)
C-6xHis-Avi (3)
C-Avi (4)
C-Avi-6xHis (5)
C-Fc (1)
C-Flag (3)
C-GST (1)
C-His (95)
C-His-Avi (27)
C-hFc (87)
C-hFc-6xHis (2)
C-hFc-Avi (8)
C-mFc (16)
C-rFc (2)
His (60)
N-6xHis-Flag (1)
N-8xHis (1)
N-Flag (7)
N-GST (2)
N-His-Avi (7)
N-hFc (2)
N-hFc-Flag (1)
Tag Free (12)
hFc (31)
Cat No. product name / Synonyms Species Expression System
TMPJ-00063 CD160 Protein, Human, Recombinant (hFc)
CD160 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
CD160 antigen is a Lipid-anchor that exists as a disulfide-linked homomultimer. CD160 contains one Ig-like V-type domain. The human CD160 precursor is a cysteine...
TMPJ-00107 CTLA-4 Protein, Human, Recombinant (Flag)
CTLA-4 Protein, Human, Recombinant (Flag)
Human HEK293 Cells
CTLA-4 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 20 KDa and the accession numb...
TMPJ-00108 CTLA-4 Protein, Human, Recombinant (GST)
CTLA-4 Protein, Human, Recombinant (GST)
Human HEK293 Cells
CTLA-4 Protein, Human, Recombinant (GST) is expressed in HEK293 mammalian cells with C-GST tag. The predicted molecular weight is 40-55 KDa and the accession num...
TMPJ-00129 BTLA Protein, Human, Recombinant (His)
BTLA Protein, Human, Recombinant (His)
Human HEK293 Cells
B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induc...
TMPJ-00173 TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His)
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His)
Mouse HEK293 Cells
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 ...
TMPJ-00174 TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)
Mouse HEK293 Cells
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 ...
TMPJ-00175 B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
Rhesus HEK293 Cells
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas,...
TMPJ-00176 B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human HEK293 Cells
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellula...
TMPJ-00179 LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated
LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated
Human HEK293 Cells
LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weigh...
TMPJ-00181 PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-...
TMPJ-00182 PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human HEK293 Cells
PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 70-95 KDa...
TMPJ-00183 PD-L1 Protein, Human, Recombinant (Flag)
PD-L1 Protein, Human, Recombinant (Flag)
Human HEK293 Cells
PD-L1 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 35-40 KDa and the accession nu...
TMPJ-00187 CD300A Protein, Human, Recombinant (hFc & His)
CD300A Protein, Human, Recombinant (hFc & His)
Human HEK293 Cells
CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of...
TMPJ-00189 TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)ex...
TMPJ-00195 FGL1 Protein, Cynomolgus, Recombinant (Avi & His), Biotinylated
FGL1 Protein, Cynomolgus, Recombinant (Avi & His), Biotinylated
Cynomolgus HEK293 Cells
FGL1 Protein, Cynomolgus, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 36...
TMPJ-00197 FGL1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
FGL1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human HEK293 Cells
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfami...
TMPJ-00198 FGL1 Protein, Human, Recombinant (Avi & His), Biotinylated
FGL1 Protein, Human, Recombinant (Avi & His), Biotinylated
Human HEK293 Cells
FGL1 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 35 KDa ...
TMPJ-00203 Galectin-9 Protein, Human, Recombinant (GST)
Galectin-9 Protein, Human, Recombinant (GST)
Human E. coli
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galect...
TMPJ-00208 CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human HEK293 Cells
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 60-70 KDa ...
TMPJ-00209 CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
Human HEK293 Cells
CD47 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 30-40 K...
CD160 Protein, Human, Recombinant (hFc)
TMPJ-00063
CD160 antigen is a Lipid-anchor that exists as a disulfide-linked homomultimer. CD160 contains one Ig-like V-type domain. The human CD160 precursor is a cysteine...
CTLA-4 Protein, Human, Recombinant (Flag)
TMPJ-00107
CTLA-4 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 20 KDa and the accession numb...
CTLA-4 Protein, Human, Recombinant (GST)
TMPJ-00108
CTLA-4 Protein, Human, Recombinant (GST) is expressed in HEK293 mammalian cells with C-GST tag. The predicted molecular weight is 40-55 KDa and the accession num...
BTLA Protein, Human, Recombinant (His)
TMPJ-00129
B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induc...
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His)
TMPJ-00173
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 ...
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)
TMPJ-00174
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 ...
B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
TMPJ-00175
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas,...
B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00176
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellula...
LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated
TMPJ-00179
LAIR1 Protein, Human, Recombinant (aa 22-163, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weigh...
PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00181
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-...
PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00182
PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 70-95 KDa...
PD-L1 Protein, Human, Recombinant (Flag)
TMPJ-00183
PD-L1 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 35-40 KDa and the accession nu...
CD300A Protein, Human, Recombinant (hFc & His)
TMPJ-00187
CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of...
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)
TMPJ-00189
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)ex...
FGL1 Protein, Cynomolgus, Recombinant (Avi & His), Biotinylated
TMPJ-00195
FGL1 Protein, Cynomolgus, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 36...
FGL1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00197
Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfami...
FGL1 Protein, Human, Recombinant (Avi & His), Biotinylated
TMPJ-00198
FGL1 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 35 KDa ...
Galectin-9 Protein, Human, Recombinant (GST)
TMPJ-00203
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galect...
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00208
CD47 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 60-70 KDa ...
CD47 Protein, Human, Recombinant (Avi & His), Biotinylated
TMPJ-00209
CD47 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 30-40 K...
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TargetMol