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Co-inhibitory Immune Checkpoint Proteins

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

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Species
Canine (8)
Cavia porcellus (1)
Cynomolgus (60)
Human (196)
Marmoset (1)
Mouse (80)
Rabbit (2)
Rat (25)
Rhesus (33)
Expression System
Baculovirus Insect Cells (5)
CHO Cells (1)
E. coli (5)
HEK293 Cells (380)
P. pastoris (Yeast) (1)
Tag
Avi (34)
C-6xHis (25)
C-6xHis-Avi (3)
C-Avi (4)
C-Avi-6xHis (5)
C-Fc (1)
C-Flag (3)
C-GST (1)
C-His (95)
C-His-Avi (27)
C-hFc (87)
C-hFc-6xHis (2)
C-hFc-Avi (8)
C-mFc (16)
C-rFc (2)
His (60)
N-6xHis-Flag (1)
N-8xHis (1)
N-Flag (7)
N-GST (2)
N-His-Avi (7)
N-hFc (2)
N-hFc-Flag (1)
Tag Free (12)
hFc (31)
Cat No. product name / Synonyms Species Expression System
TMPK-00260 CD155/PVR Protein, Human, Recombinant (His & Avi)
CD155/PVR Protein, Human, Recombinant (His & Avi)
Human HEK293 Cells
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tum...
TMPK-00286 Siglec-9 Protein, Human, Recombinant (His & Avi)
Siglec-9 Protein, Human, Recombinant (His & Avi)
Human HEK293 Cells
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results ...
TMPK-00287 Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated
Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results ...
TMPK-00310 BTN3A1 Protein, Human, Recombinant (His & Avi), Biotinylated
BTN3A1 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
TMPK-00312 Nectin-1 Protein, Human, Recombinant (His & Avi)
Nectin-1 Protein, Human, Recombinant (His & Avi)
Human HEK293 Cells
Nectin-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 36.9 kDa and the ac...
TMPK-00313 Nectin-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Nectin-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
Nectin-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 36.9 ...
TMPK-00314 B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
Human HEK293 Cells
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-00315 B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
Human HEK293 Cells
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-00470 PVRIG Protein, Mouse, Recombinant (hFc & Avi)
PVRIG Protein, Mouse, Recombinant (hFc & Avi)
Mouse HEK293 Cells
Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG...
TMPK-00471 PVRIG Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
PVRIG Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
Mouse HEK293 Cells
Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG...
TMPK-00476 CD200 Protein, Cynomolgus, Recombinant (His)
CD200 Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with...
TMPK-00530 BTLA Protein, Cynomolgus, Recombinant (His)
BTLA Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibi...
TMPK-00535 FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag)
FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag)
Cynomolgus HEK293 Cells
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
TMPK-00536 FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag), Biotinylated
FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag), Biotinylated
Cynomolgus HEK293 Cells
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
TMPK-00556 BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi)
BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi)
Cynomolgus HEK293 Cells
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
TMPK-00557 BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
Cynomolgus HEK293 Cells
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
TMPK-00559 CD300A Protein, Cynomolgus, Recombinant (Avi)
CD300A Protein, Cynomolgus, Recombinant (Avi)
Cynomolgus HEK293 Cells
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
TMPK-00560 CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated
CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated
Cynomolgus HEK293 Cells
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
TMPK-00561 CD300A Protein, Cynomolgus, Recombinant (His)
CD300A Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
TMPK-00584 BTN2A2 Protein, Mouse, Recombinant (His)
BTN2A2 Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
Butyrophilin (BTN) genes encode a set of related proteins. Cell surface BTN2A2 protein, such as the B7 family molecule programmed death ligand 1, was upregulated...
CD155/PVR Protein, Human, Recombinant (His & Avi)
TMPK-00260
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tum...
Siglec-9 Protein, Human, Recombinant (His & Avi)
TMPK-00286
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results ...
Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00287
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results ...
BTN3A1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00310
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
Nectin-1 Protein, Human, Recombinant (His & Avi)
TMPK-00312
Nectin-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 36.9 kDa and the ac...
Nectin-1 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00313
Nectin-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 36.9 ...
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
TMPK-00314
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00315
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
PVRIG Protein, Mouse, Recombinant (hFc & Avi)
TMPK-00470
Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG...
PVRIG Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
TMPK-00471
Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG...
CD200 Protein, Cynomolgus, Recombinant (His)
TMPK-00476
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with...
BTLA Protein, Cynomolgus, Recombinant (His)
TMPK-00530
B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibi...
FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag)
TMPK-00535
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag), Biotinylated
TMPK-00536
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun...
BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi)
TMPK-00556
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
TMPK-00557
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
CD300A Protein, Cynomolgus, Recombinant (Avi)
TMPK-00559
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated
TMPK-00560
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
CD300A Protein, Cynomolgus, Recombinant (His)
TMPK-00561
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential...
BTN2A2 Protein, Mouse, Recombinant (His)
TMPK-00584
Butyrophilin (BTN) genes encode a set of related proteins. Cell surface BTN2A2 protein, such as the B7 family molecule programmed death ligand 1, was upregulated...
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TargetMol