Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.
Cat No. | product name / Synonyms | Species | Expression System |
---|---|---|---|
TMPK-00260 | CD155/PVR Protein, Human, Recombinant (His & Avi)
CD155/PVR Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 Cells |
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tum... | |||
TMPK-00286 | Siglec-9 Protein, Human, Recombinant (His & Avi)
Siglec-9 Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 Cells |
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results ... | |||
TMPK-00287 | Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated
Siglec-9 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results ... | |||
TMPK-00310 | BTN3A1 Protein, Human, Recombinant (His & Avi), Biotinylated
BTN3A1 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the... | |||
TMPK-00312 | Nectin-1 Protein, Human, Recombinant (His & Avi)
Nectin-1 Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 Cells |
Nectin-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 36.9 kDa and the ac... | |||
TMPK-00313 | Nectin-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Nectin-1 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
Nectin-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 36.9 ... | |||
TMPK-00314 | B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ... | |||
TMPK-00315 | B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ... | |||
TMPK-00470 | PVRIG Protein, Mouse, Recombinant (hFc & Avi)
PVRIG Protein, Mouse, Recombinant (hFc & Avi)
|
Mouse | HEK293 Cells |
Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG... | |||
TMPK-00471 | PVRIG Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
PVRIG Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
|
Mouse | HEK293 Cells |
Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG... | |||
TMPK-00476 | CD200 Protein, Cynomolgus, Recombinant (His)
CD200 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 Cells |
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with... | |||
TMPK-00530 | BTLA Protein, Cynomolgus, Recombinant (His)
BTLA Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 Cells |
B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibi... | |||
TMPK-00535 | FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag)
FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag)
|
Cynomolgus | HEK293 Cells |
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun... | |||
TMPK-00536 | FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag), Biotinylated
FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag), Biotinylated
|
Cynomolgus | HEK293 Cells |
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immun... | |||
TMPK-00556 | BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi)
BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi)
|
Cynomolgus | HEK293 Cells |
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the... | |||
TMPK-00557 | BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
BTN3A1 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
|
Cynomolgus | HEK293 Cells |
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the... | |||
TMPK-00559 | CD300A Protein, Cynomolgus, Recombinant (Avi)
CD300A Protein, Cynomolgus, Recombinant (Avi)
|
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential... | |||
TMPK-00560 | CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated
CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated
|
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential... | |||
TMPK-00561 | CD300A Protein, Cynomolgus, Recombinant (His)
CD300A Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential... | |||
TMPK-00584 | BTN2A2 Protein, Mouse, Recombinant (His)
BTN2A2 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 Cells |
Butyrophilin (BTN) genes encode a set of related proteins. Cell surface BTN2A2 protein, such as the B7 family molecule programmed death ligand 1, was upregulated... |