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sn-Glycero-3-phosphocholine

Catalog No. T4439 CAS 28319-77-9

Synonyms: Choline Alfoscerate, Glycerophosphocholine, Glycerophosphorylcholine, Alpha-GPC, Choline glycerophosphate, L-α-GPC

sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia. sn-Glycero-3-phosphocholine rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].

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sn-Glycero-3-phosphocholine Chemical Structure

sn-Glycero-3-phosphocholine, CAS 28319-77-9

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Purity: 98.53%

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Description

Synonyms	Choline Alfoscerate, Glycerophosphocholine, Glycerophosphorylcholine, Alpha-GPC, Choline glycerophosphate, L-α-GPC
Molecular Weight	257.22
Formula	C8H20NO6P
CAS No.	28319-77-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mM

References and Literature

1. Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9. 2. Barbagallo Sangiorgi G, et al. Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69.

Citations

1. Qiao K, Han J, Zhang H, et al.Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma.Cell Reports.2023, 42(12).

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Human Endogenous Metabolite Library Anti-COVID-19 Compound Library NO PAINS Compound Library Anti-Alzheimer's Disease Compound Library Human Endogenous Metabolite Compound Library Plus Neuronal Signaling Compound Library Approved Drug Library Bioactive Lipid Compound Library

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Keywords

sn-Glycero-3-phosphocholine 28319-77-9 Metabolism Neuroscience Endogenous Metabolite AChE Choline Alfoscerate Glycerophosphocholine Inhibitor L-alpha-GPC Glycerophosphorylcholine Alpha-GPC inhibit Choline glycerophosphate a-GPC snGlycero3phosphocholine Cholinesterase (ChE) L-α-GPC sn Glycero 3 phosphocholine α-GPC L-a-GPC inhibitor

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