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Adenosine 5'-diphosphate

Name: Adenosine 5'-diphosphate
Brand: TargetMol
SKU: T1723
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1723Cas No. 58-64-0

Alias ADP, adenosine pyrophosphate, Adenosine diphosphate

Adenosine 5'-diphosphate (ADP) is a naturally occurring nucleotide derived from the dephosphorylation of ATP. Adenosine 5'-diphosphate is essential for cellular metabolism and induces platelet aggregation.

Adenosine 5'-diphosphate

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Purity: 99.81%

Catalog No. T1723Alias ADP, adenosine pyrophosphate, Adenosine diphosphateCas No. 58-64-0

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$42	In Stock	In Stock
200 mg	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.81%

Color:White

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Product Introduction

Bioactivity

Description	Adenosine 5'-diphosphate (ADP) is a naturally occurring nucleotide derived from the dephosphorylation of ATP. Adenosine 5'-diphosphate is essential for cellular metabolism and induces platelet aggregation.
Targets&IC50	P2X2/3:67 nM, P2Y1:24 nM (EC50)
In vitro	METHODS: Fibroblast-like synoviocytes FLS1 were treated with Adenosine 5'-diphosphate (100 µM) for 24 h, and gene expression levels were measured by RT-qPCR. RESULTS: MCP-1/CCL-2 mRNA expression was up-regulated 2.31-fold in FLS1 cells treated with Adenosine 5'-diphosphate (100 µM). [1]
In vivo	METHODS: To investigate the role in tissue repair, Adenosine 5'-diphosphate (15.2 µg/kg) was applied topically to diabetic mice in a total excisional wound model once daily for 14 days. RESULTS: Adenosine 5'-diphosphate accelerated cutaneous wound healing, improved new tissue formation, and increased collagen deposition and TGF-β production in the wounds.Adenosine 5'-diphosphate acts as a pro-absorptive mediator in diabetes-related cutaneous wounds. [2]
Synonyms	ADP, adenosine pyrophosphate, Adenosine diphosphate

Chemical Properties

Molecular Weight	427.2
Formula	C₁₀H₁₅N₅O₁₀P₂
Cas No.	58-64-0
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(=O)(O)O)(=O)O)[C@H]1O
Relative Density.	2.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (234.08 mM), Sonication is recommended.

DMSO: 14 mM, Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3408 mL	11.7041 mL	23.4082 mL	117.0412 mL
5 mM	0.4682 mL	2.3408 mL	4.6816 mL	23.4082 mL
10 mM	0.2341 mL	1.1704 mL	2.3408 mL	11.7041 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1170 mL	0.5852 mL	1.1704 mL	5.8521 mL
50 mM	0.0468 mL	0.2341 mL	0.4682 mL	2.3408 mL
100 mM	0.0234 mL	0.1170 mL	0.2341 mL	1.1704 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc