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YH-306

Catalog No. T24642 CAS 1373764-75-0

Synonyms: YH306, TRV055 acetate (25849-90-5 Free base)

YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.

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YH-306, CAS 1373764-75-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 372.00
200 mg	In stock	$ 549.00
500 mg	In stock	$ 869.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

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Purity: 97.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
In vitro	YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1, and the expression of MMP2 and MMP9. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 inhibits Arp2/3 complex-mediated actin polymerization[1].

Synonyms	YH306, TRV055 acetate (25849-90-5 Free base)
Molecular Weight	306.36
Formula	C19H18N2O2
CAS No.	1373764-75-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15 mg/mL (48.96 mM), when pH is adjusted to 1 with HCl. Sonication is recommended.

References and Literature

1. Dai F, et al. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19(2):383-95.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Antidepressant Compound Library Anti-Ovarian Cancer Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library Metabolism Compound Library Neuronal Differentiation Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YH-306 1373764-75-0 Angiogenesis Cell Cycle/Checkpoint Cytoskeletal Signaling PI3K/Akt/mTOR signaling Proteases/Proteasome Tyrosine Kinase/Adaptors MMP FAK Rho PI3K Src 25849-90-5 YH 306 YH306 TRV 055 Acetate TRV055 acetate (25849-90-5 Free base) TRV055 Acetate 25849-90-5 Free base TRV-055 Acetate inhibitor inhibit

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