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YH-306

Catalog No. T24642 CAS 1373764-75-0

Synonyms: YH 306, YH306

YH-306 is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.

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YH-306, CAS 1373764-75-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	YH-306 is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
In vitro	YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1, and the expression of MMP2 and MMP9. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 inhibits Arp2/3 complex-mediated actin polymerization[1].

Synonyms	YH 306, YH306
Molecular Weight	306.36
Formula	C19H18N2O2
CAS No.	1373764-75-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 15 mg/mL?(48.96 mM), ultrasonic and adjust pH to 1 with HCl

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Dai F, et al. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19(2):383-95.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

YH-306 1373764-75-0 TRV055 acetate (25849-90-5 Free base) Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.