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Vipivotide tetraxetan

Catalog No. T12573 CAS 1702967-37-0

Synonyms: PSMA-617

Vipivotide tetraxetan (PSMA-617) is a high potent inhibitor of prostate-specific membrane antigen (PSMA)(Ki of 0.37 nM).

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Vipivotide tetraxetan Chemical Structure

Vipivotide tetraxetan, CAS 1702967-37-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 193.00
2 mg	In stock	$ 287.00
5 mg	In stock	$ 483.00
10 mg	In stock	$ 691.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,490.00
100 mg	In stock	$ 1,960.00
1 mL * 10 mM (in DMSO)	In stock	$ 1,190.00

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Purity: 100%

Purity: 98.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Vipivotide tetraxetan (PSMA-617) is a high potent inhibitor of prostate-specific membrane antigen (PSMA)(Ki of 0.37 nM).
Targets&IC50	PSMA:0.37 nM(Ki)
In vitro	The chemically modified PSMA inhibitor PSMA-617 demonstrated high radiolytic stability for at least 72 h. A high inhibition potency (equilibrium dissociation constant [K(i)] = 2.34 2.94 nM on LNCaP; K(i) = 0.37 0.21 nM enzymatically determined) and highly efficient internalization into LNCaP cells were demonstrated.
In vivo	The small-animal PET measurements showed high tumor-to-background contrasts as early as 1 h after injection of Vipivotide tetraxetan.Organ distribution revealed specific uptake in LNCaP tumors and in the kidneys 1 h after injection of Vipivotide tetraxetan[1].

Synonyms	PSMA-617
Molecular Weight	1042.14
Formula	C49H71N9O16
CAS No.	1702967-37-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (95.96 mM), Sonication is recommended.

H2O: 100 mg/mL (95.96 mM)

References and Literature

1. Benešová M, et al. Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer. J Nucl Med. 2015 Jun;56(6):914-20.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Inhibitor Library Bioactive Compounds Library Max Clinical Compound Library Bioactive Compound Library Human Metabolite Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Vipivotide tetraxetan 1702967-37-0 Others Inhibitor PSMA-617 PSMA 617 Drug-Linker Conjugates for ADC inhibit PSMA617 inhibitor

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