Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 72.00 | |
50 mg | In stock | $ 128.00 | |
100 mg | In stock | $ 198.00 | |
500 mg | In stock | $ 513.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 42.00 |
Description | Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively. |
Targets&IC50 | 5-HT3 receptor:70.1 ± 0.9 nM, 5-HT3 receptor:5.3 nM(Ki), α7 nAChR:6.9 nM(Ki) |
In vivo | Tolbisetron induces anti-inflammatory effects in experimental models of cisplatin-induced nephrotoxicity that are completely independent of the 5-HT3 receptor. Tropisetron can improve ischemic brain injury by reducing TNF-α levels and myeloperoxidase activity[3]. |
Synonyms | Tropisetronum, Tropisteron, ICS 205-930 |
Molecular Weight | 284.35 |
Formula | C17H20N2O2 |
CAS No. | 89565-68-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL(175.84 mM)
DMSO: 8 mg/mL(28.13 mM)
You can also refer to dose conversion for different animals. More
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Tropisetron 89565-68-4 GPCR/G Protein Neuroscience 5-HT Receptor AChR 5-hydroxytryptamine Receptor nAChR Tropisetronum Tropisteron Nicotinic acetylcholine receptors Serotonin Receptor Inhibitor inhibit ICS 205-930 inhibitor