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Schisandrin C

Catalog No. T5S1923   CAS 61301-33-5
Synonyms: Wuweizisu-C, Schizandrin-C, Wuweizisu-C, Schizandrin-C

Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.

Schisandrin C, CAS 61301-33-5
Pack Size Availability Price/USD Quantity
2 mg In stock 50.00
10 mg In stock 151.00
1 mL * 10 mM (in DMSO) In stock 61.00
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Purity 99.98%
Purity 99.56%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
Targets&IC50 Others
In vitro Schisandrin C inhibited cell growth in a dose-dependent manner, which was associated with the induction of G1 arrest of the cell cycle and apoptosis. Schisandrin C induced G1 arrest was correlated with down-regulation of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, inhibition of phosphorylation of retinoblastoma protein (pRB), and up-regulation of the Cdk inhibitor p21(WAF1/CIP1). In addition, schisandrin C-induced apoptosis was associated with down-regulation of expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL, proteolytic activation of caspase-3 and -9, and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). Furthermore, schisandrin C-induced apoptosis was significantly inhibited by a caspase-3 specific inhibitor z-DEVD-fmk . Schisandrin C was found to reduce nitric oxide (NO) production from LPS-stimulated Raw 264.7 cells. Pre-treatment of Raw 264.7 cells with gomisin J, gomisin N, or schisandrin C reduced the expression of mRNA and the secretion of pro-inflammatory cytokines .
Synonyms Wuweizisu-C , Schizandrin-C , Wuweizisu-C , Schizandrin-C
Purity 99.98%
Molecular Weight 384.42
Formula C22H24O6
CAS No. 61301-33-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. E Q, Tang M, et al.Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells.Cell Biol Int. 2015 Dec;39(12):1418-24 2. Oh SY, et al. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Biosci Biotechnol Biochem. 2010;74(2):285-91.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Natural Compound Library for HTS Anti-cancer Compound Library Anti-infection Compound Library Apoptosis Compound Library Immunology/Inflammation Compound Library Selected Plant-sourced Compound Library Anti-gastroenteritis Natural Product Library Anti-aging Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Active Compound library Ferroptosis Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Tibetan medicine Compound Library Traditional Chinese Medicine Monomer Library

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