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SKLB-163

Name: SKLB-163
Brand: TargetMol
SKU: T26193
Price: 137 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SKLB163) Copy Product Info

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Synonyms: SKLB163

Catalog No. T26193 Copy Product Info

Purity: 99.23%

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SKLB-163 is a small-molecule inhibitor and a RhoGDI inhibitor with oral bioactivity, cell permeability, and selectivity. This compound induces tumor cell apoptosis, inhibits proliferation and migration, and enhances radiosensitivity by downregulating RhoGDI, activating the JNK-1/caspase-3 pathway, and suppressing Akt and p44/42 MAPK phosphorylation.

Cas No. 1255099-06-9

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Pack Size	Price	USA Stock	Global Stock
1 mg	$137	In Stock	In Stock
5 mg	$336	In Stock	In Stock
10 mg	$497	In Stock	In Stock
25 mg	$793	In Stock	In Stock
50 mg	$1,130	In Stock	In Stock
100 mg	$1,520	In Stock	In Stock
500 mg	$2,970	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$373	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.23%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

SKLB-163 AI Summary

SKLB-163 exhibits cytotoxic and antiproliferative activities against a variety of human cancer cell lines. As determined by MTT assay after 48 hours, it shows IC50 values ranging from 1100.0 nM to 6580.0 nM, indicating its potency in inhibiting cell growth by 50% across different cell types, including MCF7, HepG2, HeLa, A-375, SPCA1, SW620, and PC-3 cells. Lower IC50 values suggest higher potency in inhibiting the growth of these cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SKLB-163 is a small-molecule inhibitor and a RhoGDI inhibitor with oral bioactivity, cell permeability, and selectivity. This compound induces tumor cell apoptosis, inhibits proliferation and migration, and enhances radiosensitivity by downregulating RhoGDI, activating the JNK-1/caspase-3 pathway, and suppressing Akt and p44/42 MAPK phosphorylation.
Targets & IC50	A431 cells:4.4 μM, HCT116 cells:1.3 μM, A549 cells:4 μM, A375 cells:1.8 μM, BxPC-3 cells:6.6 μM
In vitro	Methods: Nasopharyngeal carcinoma (NPC) cells were treated with various concentrations (0–20 μM) of SKLB-163 for 48 h, and changes in cell proliferation, migration, and radiosensitivity were detected. Results: SKLB-163 inhibited proliferation and migration of nasopharyngeal carcinoma (NPC) cells and sensitized the cells to radiation. [1] Methods: A375, SPC-A1, SW620, HeLa, and PC-3 cells were treated with various concentrations (0–20 μM) of SKLB-163 for 48 h to detect cytotoxic effects. A375 cells were treated with various concentrations (0–2.5 μM) of SKLB-163 for 48 h to detect apoptosis and colony formation. Results: SKLB-163 showed cytotoxic effects in A375, SPC-A1, SW620, HeLa, and PC-3 cells, and could induce apoptosis and inhibit colony formation in A375 cells. [2]
In vivo	Methods: To detect in vivo antitumor and radiosensitizing effects, SKLB-163 (25–100 mg/kg, gavage, once daily for 30 days) was administered alone in a nasopharyngeal carcinoma mouse model, or combined with radiotherapy (3 Gy radiation once daily for 3 days starting on day 6 of SKLB-163 administration). Results: SKLB-163 alone inhibited tumor growth and ascites formation, and suppressed liver and lung metastasis; combined administration sensitized nasopharyngeal carcinoma tumors to radiation. [1]
Synonyms	SKLB163

Chemical Properties

Molecular Weight	405.92
Formula	C₁₈H₁₆ClN₃O₂S₂
Cas No.	1255099-06-9
Smiles	S(CC(NCC1=CC=CC=C1)=O)C2=NC=3C(S2)=CC(NC(CCl)=O)=CC3
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247.5 mg/mL (609.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4635 mL	12.3177 mL	24.6354 mL	123.1770 mL
5 mM	0.4927 mL	2.4635 mL	4.9271 mL	24.6354 mL
10 mM	0.2464 mL	1.2318 mL	2.4635 mL	12.3177 mL
20 mM	0.1232 mL	0.6159 mL	1.2318 mL	6.1588 mL
50 mM	0.0493 mL	0.2464 mL	0.4927 mL	2.4635 mL
100 mM	0.0246 mL	0.1232 mL	0.2464 mL	1.2318 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.