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S 38093 HCl

Catalog No. T4087 CAS 1222097-72-4

S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.

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S 38093 HCl, CAS 1222097-72-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 79.00
5 mg	In stock	$ 165.00
10 mg	In stock	$ 235.00
25 mg	In stock	$ 419.00
50 mg	In stock	$ 598.00
100 mg	In stock	$ 853.00
1 mL * 10 mM (in DMSO)	In stock	$ 168.00

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Purity: 99.16%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.

Kinase Assay

PI3K inhibition by LY294002 is determined in a radiometric assay using purified, recombinant enzymes with 1 μM ATP. The kinase reaction is carried out for 1 hour at room temperature (24oC) and is terminated by addition of PBS. IC50 values are subsequently determined using a sigmoidal dose-response curve fit (variable slope). CK2 and GSK3β (glycogen synthase kinase 3β) inhibition are established by kinase selectivity screening. LY294002 is tested against the Upstate panel of kinases in 10 μM ATP.[4]

Molecular Weight	324.85
Formula	C17H25ClN2O2
CAS No.	1222097-72-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (76.96 mM)

References and Literature

1. Guilloux JP, et al. S 38093, a histamine H(3) antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library NO PAINS Compound Library Histamine & Melatonin Receptor-Targeted Compound Library Neuronal Signaling Compound Library

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Keywords

S 38093 HCl 1222097-72-4 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor inhibitor inhibit

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