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Rotundine

Catalog No. T6648 CAS 483-14-7

Synonyms: Gindarine, L-Tetrahydropalmatine, Caseanine, (-)-Tetrahydropalmatine

Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

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Rotundine, CAS 483-14-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 36.00
50 mg	In stock	$ 52.00
100 mg	In stock	$ 75.00
500 mg	In stock	$ 183.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 100%

Purity: 99.8%

Purity: 99.73%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
Targets&IC50	D1 receptor:166 nM
In vitro	Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]
Source	Natural Products > Menispermaceae > Stephania

Synonyms	Gindarine, L-Tetrahydropalmatine, Caseanine, (-)-Tetrahydropalmatine
Molecular Weight	355.43
Formula	C21H25NO4
CAS No.	483-14-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8 mg/mL (22.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Wang JB, et al. Future Med Chem, 2012, 4(2), 177-186. 2. Liu YL, et al. Acta Pharmacol Sin, 2005, 26(5), 533-538.

Citations

1. Wu D, Wang P, Zhao C, et al.Levo-tetrahydropalmatine Ameliorates Neuropathic Pain by Inhibiting the Activation of the Clec7a-MAPK/NF-κB-NLRP3 Inflammasome Axis.Phytomedicine.2023: 155075.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Parkinson's Disease Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Natural Product Library for HTS Chinese Pharmacopoeia Natural Product Library Traditional Chinese Medicine Monomer Library Endocrinology-Hormone Compound Library Natural Product Library Approved Drug Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rotundine 483-14-7 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor 5-hydroxytryptamine Receptor Inhibitor Gindarine Tetrahydropalmatine L-Tetrahydropalmatine Caseanine inhibit Serotonin Receptor (-)-Tetrahydropalmatine inhibitor

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