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Remdesivir

Catalog No. T7766 CAS 1809249-37-3

Synonyms: GS-5734

Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)

Remdesivir, CAS 1809249-37-3

Pack Size	Availability	Price/USD
1 mg	In stock	189.00
5 mg	In stock	474.00
10 mg	In stock	703.00
1 mL * 10 mM (in DMSO)	In stock	713.00

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Purity 97.62%

HNMR HPLC COA

Purity 99.90%

HNMR HPLC COA

Purity 99.93%

HNMR HPLC COA

HNMR COA

Purity 99.95%

HNMR HPLC COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
Targets&IC50	SARS-CoV , MERS-CoV , MHV

Synonyms	GS-5734
Purity	97.62%
Molecular Weight	602.58
Formula	C27H35N6O8P
CAS No.	1809249-37-3

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 125 mg/mL (207.44 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Agostini M L , Andres E L , Sims A C , et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease[J]. Mbio, 2018, 9(2):e00221-18. 2. Wang M , Cao R , Zhang L , et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro[J]. cell research. 3. Silvas J A, Jureka A S, Nicolini A M, et al. Inhibitors of VPS34 and lipid metabolism suppress SARS-CoV-2 replication[J]. bioRxiv. 2020. 4. Nguyenla X, Wehri E, Van Dis E, et al. Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells[J]. bioRxiv. 2020 5. Li Y, Cao L, Li G, et al. Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model[J] . Journal of medicinal chemistry. 2020

Related compound libraries

This product is contained In the following compound libraries：

Approved Drug Library Bioactive Compound Library Clinical Compound Library Anti-virus Compound Library FDA-approved Drug Library DNA Damage & Repair Compound Library Drug Repurposing Library Anti-COVID-19 Compound Library FDA Approved & Pharmacopeial Drug Library

Related Products

Related compounds with same targets

GRL0617 PLpro inhibitor O-Methylbroussochalcone B Arteannuin B Remdesivir EIDD-2801 ML188 XP-59

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.