Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viruses, and is potentially therapeutic against COVID-19.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 122.00 | |
5 mg | In stock | $ 339.00 | |
10 mg | In stock | $ 537.00 | |
25 mg | In stock | $ 797.00 | |
50 mg | In stock | $ 1,120.00 | |
100 mg | In stock | $ 1,510.00 | |
200 mg | In stock | $ 1,990.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 450.00 |
Description | Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viruses, and is potentially therapeutic against COVID-19. |
Targets&IC50 | SARS-CoV:74 nM (EC50) , MERS-CoV:74 nM (EC50) |
In vitro |
METHODS: Mouse hepatitis virus (MHV)-infected DBT cells were incubated with Remdesivir (0.01-1 µM) for 24 h, and the supernatant was analyzed for viral titer by plaque assay. RESULTS: Remdesivir effectively inhibited MHV with an EC50 of 0.03 µM. [1] METHODS: 2019-nCoV-infected Vero E6 cells were treated with Remdesivir (0-400 µM) for 48 h. Viral yield in cell supernatants was detected using qRT-PCR. RESULTS: Remdesivir effectively blocked viral infection at low micromolar concentrations and showed high SI (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87). [2] |
In vivo |
METHODS: To assay antiviral activity in vivo, Remdesivir (25 mg/kg, 12% sulfobutylether-β-cyclodextrin sodium salt in water (with HCl/NaOH) at pH 5.0) was injected subcutaneously into MERS-CoV-infected Ces1c-/- hDPP4 mice twice daily. RESULTS: Prophylactic Remdesivir reduced MERS-CoV replication and disease. [3] METHODS: To assay antiviral activity in vivo, Remdesivir (25 mg/kg once daily, administered three times) and Loratadine (10 mg/kg once daily, administered four times) were administered intraperitoneally to 501Y.V2 SARS-CoV-2 infected BALB/c mice. RESULTS: The combination of Remdesivir and the antihistamine Loratadine reduced SARS-CoV-2 replication and inflammation and protected against lung injury. [4] |
Synonyms | GS-5734 |
Molecular Weight | 602.58 |
Formula | C27H35N6O8P |
CAS No. | 1809249-37-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (207.44 mM)
You can also refer to dose conversion for different animals. More
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Remdesivir 1809249-37-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology DNA/RNA Synthesis SARS-CoV COVID-19 GS-5734 MERS-CoV GS5734 2019-nCoV antiviral SARS coronavirus Inhibitor inhibit infection GS 5734 inhibitor