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Pyridoxylamine

Catalog No. T12588 CAS 85-87-0

Synonyms: pyridoxamine

Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).

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Pyridoxylamine, CAS 85-87-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 38.00
25 mg	In stock	$ 61.00
50 mg	In stock	$ 89.00
100 mg	In stock	$ 128.00
1 mL * 10 mM (in DMSO)	In stock	$ 147.00

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Purity: 99.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs).
In vitro	Pyridoxylamine (PM) is a member of the B6 vitamer family,and is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1].
In vivo	In STZ diabetic rats, Pyridoxylamine inhibited the formation of CML and CEL and the cross-linking of skin collagen, ultimately inhibiting the development of nephropathy. Pyridoxamine does not appear to act as an antioxidant because it does not inhibit lipid peroxidation. However, it prevents modification of proteins by lipid peroxidation products, including inhibition of the formation of adducts of malondialdehyde and 4-hydroxynonenal on proteins in Zucker rats [1].

Synonyms	pyridoxamine
Molecular Weight	168.19
Formula	C8H12N2O2
CAS No.	85-87-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.25 mg/mL (185.80 mM), Sonication is recommended.

H2O: 6.25 mg/mL (37.16 mM), Sonication is recommended.

References and Literature

1. Stitt A, et al. The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes. Diabetes. 2002 Sep;51(9):2826-32.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Inhibitor Library ReFRAME Related Library Bioactive Compounds Library Max Natural Product Library Human Endogenous Metabolite Compound Library Plus Selected Plant-Sourced Compound Library Natural Product Library for HTS RO5 Drug-like Natural Product Library Bioactive Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pyridoxylamine 85-87-0 Metabolism Endogenous Metabolite pyridoxamine inhibit Inhibitor inhibitor

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