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Theaflavin

Catalog No. T7602 CAS 4670-05-7

Theaflavin is a polyphenolic flavonoid that has been found in black tea and has diverse biological activities, including antioxidant, anticancer, anti-inflammatory, and antiviral properties

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Theaflavin, CAS 4670-05-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 108.00
10 mg	In stock	$ 160.00
25 mg	In stock	$ 238.00
50 mg	In stock	$ 352.00
100 mg	In stock	$ 523.00
1 mL * 10 mM (in DMSO)	In stock	$ 153.00

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Purity: 98%

Purity: 95.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Theaflavin is a polyphenolic flavonoid that has been found in black tea and has diverse biological activities, including antioxidant, anticancer, anti-inflammatory, and antiviral properties
In vitro	Theaflavin inhibits the growth of OVCAR-3 and A2780/CP70 human ovarian cancer cell lines, but not the ovarian epithelial cell line IOSE 364 (IC50s = 11.9, 38.5, and >40 μM, respectively)[1].
In vivo	In the pretreated ICH rats TF significantly alleviated the behavioral defects, protected BBB integrity, and decreased the formation of cerebral edema and the levels of ROS as well as inflammatory cytokines (including interleukin-1 beta [IL-1β], IL-18, tumor nectosis factor-alpha, interferon-γ, transforming growth factor beta, and (C-X-C motif) ligand 1 [CXCL1]).?Nissl staining and TUNEL displayed TF could protect against the neuron loss and apoptosis via inhibiting the activation of nuclear transcription factor kappa-β-p65 (NF-κβ-p65), caspase-1, and IL-1β[2].
Cell Research	Cell proliferation assay, Hoechst 33342 staining assay, Caspase-Glo Assay, western blot, human umbilical vein endothelial cell tube formation assay and vascular endothelial growth factor (VEGF) enzyme-linked immunosorbent assay were performed[1].
Animal Research	ICH rat models were induced with type VII collagenase and pretreated with TF by gavage in different doses (25 mg/kg-100 mg/kg).?Twenty-four hours after ICH attack, evaluated the rats' behavioral performance, the blood-brain barrier (BBB) integrity, and the formation of cerebral edema.?The levels of reactive oxygen species (ROS) and inflammatory cytokines were examined by 2',7'-dichlorofluorescin diacetate and enzyme-linked immunosorbent assay.?Nissl staining and transferase dUTP nick end labeling (TUNEL) were aimed to detect the neuron loss and apoptosis, the mechanism of which was explored by Western blot[2].
Source	Natural Products > Theaceae > Camellia

Molecular Weight	564.49
Formula	C29H24O12
CAS No.	4670-05-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.65 mg/mL (10 mM), Sonification is recommended

References and Literature

1. Gao Y , Rankin G O , Youying T U , et al. Inhibitory Effects of the Four Main Theaflavin Derivatives Found in Black Tea on Ovarian Cancer Cells[J]. Anticancer research, 2016, 36(2):643-651. 2. Guanglei F , Hua W , Youli C , et al. Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats[J]. Drug Design, Development and Therapy, 2018, Volume 12:1609-1619. 3. Juarez-Mercado K E, Prieto-Martinez F D, Sanchez-Cruz N, et al. DNA Methyltransferase Inhibitors with Novel Chemical Scaffolds[J]. bioRxiv. 2020 4. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors[J]. Pharmaceuticals. 2021, 14(1): 17.

Citations

1. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors. Pharmaceuticals. 2021, 14(1): 17. 2. Yang X, Liu L, Hao Y, et al. A Bioluminescent Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and In Vitro. Viruses. 2021, 13(6): 1055.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Fibrosis Compound Library Ferroptosis Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Antioxidant Compound Library Anti-COVID-19 Compound Library Anti-virus Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Immunology/Inflammation Compound Library Selected Plant-Sourced Compound Library

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Keywords

Theaflavin 4670-05-7 Metabolism Microbiology/Virology Influenza Virus Endogenous Metabolite inhibit Inhibitor inhibitor

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