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1,3-Dihydroxyacetone

Name: 1,3-Dihydroxyacetone
Brand: TargetMol
SKU: T41122
Rating: 4.5 (1 reviews)

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Catalog No. T41122Cas No. 96-26-4

1,3-Dihydroxyacetone is the main active ingredient in sunscreen tanning skin care preparations, an important precursor for the synthesis of a variety of fine chemicals, and a food additive that can be produced on an industrial scale by microbial fermentation on Gluconobacter oxydans. 1,3-Dihydroxyacetone has the ability to increase cAMP levels. 1,3-Dihydroxyacetone has the ability to increase cAMP levels.

1,3-Dihydroxyacetone

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Catalog No. T41122Cas No. 96-26-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$30	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:≥98%

Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

1,3-Dihydroxyacetone AI Summary

1,3-Dihydroxyacetone has demonstrated various bioactivities and significant inhibitory effects on multiple biological targets. It shows a 15.0% inhibition of Human acrosin activity via ketoses. The compound exhibits notable trypanocidal activity against Trypanosoma brucei bloodstream form, achieving 100.0% activity at concentrations of 4 mM and 5 mM after 24 hours, with an IC50 value of 1,030,000.0 nM determined by phosphatase activity assays. Additionally, 1,3-Dihydroxyacetone induces necrosis with activities ranging from 4.0% to 12.9% at different concentrations, causes cell cycle arrest at the G2/M and G2 phases at 2 mM (up to 70.0% and 50.0% respectively), and promotes apoptosis-like programmed cell death featuring loss of mitochondrial-membrane potential, phosphatidylserine exposure, and increased intracellular reactive oxygen species production, with activities from 4.9% to 33.6%. Furthermore, it exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells, showing IC50 values above 19,952.62 nM and 20,000.0 nM. Overall, 1,3-Dihydroxyacetone significantly impacts viral and parasitic infections, as well as key cellular processes associated with survival and apoptosis..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	90.08
Formula	C₃H₆O₃
Cas No.	96-26-4
Smiles	OCC(=O)CO

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (555.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (22.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	11.1012 mL	55.5062 mL	111.0124 mL	555.0622 mL
5 mM	2.2202 mL	11.1012 mL	22.2025 mL	111.0124 mL
10 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
20 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
50 mM	0.2220 mL	1.1101 mL	2.2202 mL	11.1012 mL
100 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc