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Perindopril erbumine

Catalog No. T1484L CAS 107133-36-8

Synonyms: S9490-3, Perindopril tert-butylamine salt

Perindopril Erbumine is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl Angiotensin-converting Enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.

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Perindopril erbumine, CAS 107133-36-8

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 52.00
200 mg	In stock	$ 78.00

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Purity: 99.8%

Purity: 99.75%

Purity: 99.23%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Perindopril Erbumine is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.

Targets&IC50

ACE:1.05 nM

Synonyms	S9490-3, Perindopril tert-butylamine salt
Molecular Weight	441.61
Formula	C23H43N3O5
CAS No.	107133-36-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: 50 mg/mL (113.22 mM)

DMSO: 10 mg/mL (22.64 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ceconi C, et al. Eur J Pharmacol, 2007, 577(1-3), 1-6. 2. Zou K, et al. J Biol Chem, 2009, 284(46), 31914-31920. 3. Yasumatsu R, et al. J Cancer Res Clin Oncol, 2004, 130(10), 567-573. 4. Yoshiji H, et al. Clin Cancer Res, 2001, 7(4), 1073-1078. 5. Ceconi C, et al. Cardiovasc Drugs Ther, 2007, 21(6), 423-429.

Related compound libraries

This product is contained In the following compound libraries：

Orally Active Compound Library Anti-Cancer Approved Drug Library NO PAINS Compound Library ReFRAME Related Library NMPA-Approved Drug Library Drug-induced Liver Injury (DILI) Compound Library Approved Drug Library Endocrinology-Hormone Compound Library Inhibitor Library Nonsteroidal Anti-Inflammatory Compound Library

Related Products

Related compounds with same targets

Pomisartan Pomisartan 2HCl L-162,313 Ripisartan ACT 178882 Pivalopril L162441 AVE 0991

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Keywords

Perindopril erbumine 107133-36-8 Apoptosis Endocrinology/Hormones Immunology/Inflammation RAAS MRP S9490-3 S 9490 inhibit Perindopril tert-butylamine Perindopril S-9490 Inhibitor Angiotensin-converting Enzyme (ACE) Perindopril tert-butylamine salt S9490 inhibitor

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