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Paroxetine hydrochloride

Catalog No. T1636 CAS 78246-49-8

Synonyms: Paroxetine HCl, 盐酸帕罗西汀, BRL29060 hydrochloride, FG-7051, BRL29060A

Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.

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Paroxetine hydrochloride, CAS 78246-49-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
Targets&IC50	GRK2:14 μM
Cell Research	Paroxetine is dissolved in DMSO. Cell viability is determined by the tetrazolium salt 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. BV2 and primary microglial cells are initially seeded into 96-well plates at a density of 1×104 cells/well and 5×104 cells/well, respectively. Following treatment, MTT (5 mg/mL in PBS) is added to each well and incubated at 37°C for four hours. The resulting formazan crystals are dissolved in dimethylsulfoxide (DMSO). The optical density is measured at 570 nm, and results are expressed as a percentage of surviving cells compared with the control.

Synonyms	Paroxetine HCl, 盐酸帕罗西汀, BRL29060 hydrochloride, FG-7051, BRL29060A
Molecular Weight	365.83
Formula	C19H21ClFNO3
CAS No.	78246-49-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 10 mg/mL (27.33 mM)

Ethanol: 35 mg/mL (95.67 mM)

DMSO: 73 mg/mL (199.54 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Le Poul E, et al. Naunyn Schmiedebergs Arch Pharmacol, 1995, 352(2), 141-148. 2. von Moltke LL, et al. J Clin Psychopharmacol, 1995, 15(2), 125-131. 3. Thomas DR, et al. Psychopharmacology (Berl), 1987, 93(2), 193-200. 4. Bertelsen KM, et al. Drug Metab Dispos, 2003, 31(3), 289-293. 6. Lassen TR, et al. Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction. Basic Res Cardiol. 2017 May;112(3):26. 7. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069. 8. Wang K, Gong Q, Zhan Y, et al. Blockage of autophagic flux and induction of mitochondria fragmentation by Paroxetine hydrochloride in lung cancer cells promotes apoptosis via the ROS-MAPK pathway[J]. Frontiers in Cell and Developmental Biology. 2020, 7: 397.

Citations

1. Wang K, Gong Q, Zhan Y, et al. Blockage of autophagic flux and induction of mitochondria fragmentation by Paroxetine hydrochloride in lung cancer cells promotes apoptosis via the ROS-MAPK pathway. Frontiers in Cell and Developmental Biology. 2020, 7: 397

Related compound libraries

This product is contained In the following compound libraries：

Autophagy Compound Library GPCR Compound Library Serotonin Receptor-Targeted Compound Library Neurotransmitter Receptor Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Anti-Alzheimer's Disease Compound Library Fluorochemical Library Drug Repurposing Compound Library FDA-Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

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