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Paradol

Catalog No. T7113 CAS 27113-22-0

Synonyms: 6-paradol, [6]-Gingerone

Paradol ([6]-Gingerone) is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities,neuroprotective Effects.

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Paradol, CAS 27113-22-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 40.00
10 mg	In stock	$ 57.00
25 mg	In stock	$ 94.00
50 mg	In stock	$ 138.00
100 mg	In stock	$ 209.00
500 mg	In stock	$ 593.00
1 g	In stock	$ 945.00
1 mL * 10 mM (in DMSO)	In stock	$ 42.00

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Purity: 99.43%

Purity: 98.65%

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Description	Paradol ([6]-Gingerone) is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activities,neuroprotective Effects.
In vivo	EAE-symptomatic mice were treated with 6-shogaol or 6-paradaol (5 mg/kg, p.o.) once daily for 14 days (between days 29 and 42 after immunization).?Both 6-shogaol and 6-paradol significantly improved EAE-relevant symptoms from the fourth day after drug administration (between days 32 and 42) except days 36 and 37 in the 6-paradol-treated EAE group compared to the vehicle-treated EAE group (Fig. 1A, Supplementary Table 1). The effectiveness of 6-shogaol and 6-paradol was also clearly shown from cumulative clinical scores from days 30 to 43.?Administration of 6-paradol or 6-shogaol significantly reduced the cumulative clinical score (6-shogaol, 25.25%;?6-paradol, 25.75%) compared to the vehicle-treated EAE group.?6-shogaol and its metabolite, 6-paradaol, exert neuroprotective effects against EAE.?Moreover, these molecules are therapeutically effective for EAE[1].
Animal Research	MOG35-55 was emulsified in an equal amount of CFA.?Mice were anesthetized with isoflurane and 200 μg of emulsion MOG35-55 in CFA was injected subcutaneously at the start day of immunization (day 1). In addition, 400 ng of Bordetella pertussis toxin (PTX) per mouse was injected intraperitoneally on the start day of MOG immunization and 2 days later.?Mice were weighed and monitored daily for clinical symptoms of EAE as follows: 0, no clinical signs of EAE;?0.5, some lack of tone, however, some strength at the base of tail;?1.0, total loss of tail tonicity and flaccid tail;?2.0, hind limb weakness;?2.5, incomplete paralysis of one or both hind limbs;?3.0, total paralysis of one or both hind limbs;?4.0, hind and fore limbs paralysis;?5.0, death from disease.?For drug administration, symptomatic EAE mice were divided into three groups;?(1) the vehicle-treated EAE group, (2) the 6-shogaol-treated EAE group, and (3) the 6-paradol-treated EAE group.?Vehicle (10% Tween 80), 6-shogaol (5 mg/kg), or 6-paradol (5 mg/kg) was orally administered daily into symptomatic EAE mice from day 29 to day 42 (for 13 days) post immunization[1].
Source	Natural Products > Solanaceae > Capsicum

Synonyms	6-paradol, [6]-Gingerone
Molecular Weight	278.39
Formula	C17H26O3
CAS No.	27113-22-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 140 mg/mL (502.89 mM)

References and Literature

1. Arjun Sapkota,Se Jin Park, and Ji Woong Choi,et al.Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis[J].Biomol Ther (Seoul). 2019 Feb; 27(2): 152–159. 2. Breemen R B V , Tao Y , Li W . Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)[J]. Fitoterapia, 2011, 82(1):38-43.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Anti-Cancer Active Compound Library Anti-Aging Compound Library NO PAINS Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Food as Medicine Compound Library Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Anti-Fibrosis Compound Library Chinese Pharmacopoeia Natural Product Library

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Loxoprofen sodium [8]-Shogaol Imrecoxib (E)-Ethyl p-methoxycinnamate Fenbufen Inulicin Anatabine GW-406381

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Keywords

Paradol 27113-22-0 Immunology/Inflammation Neuroscience COX Inhibitor inhibit [6]-Paradol 6-paradol Cyclooxygenase [6]-Gingerone inhibitor

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