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Angiogenesis Src Inulicin

Inulicin

Catalog No. TQ0169   CAS 33627-41-7
Synonyms: 1-O-Acetylbritannilactone

Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.

Inulicin, CAS 33627-41-7
Pack Size Availability Price/USD Quantity
1 mg In stock 168.00
5 mg In stock 381.00
10 mg In stock 554.00
25 mg In stock 1094.00
50 mg In stock 1639.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
In vivo Administration of a single dose of Inulicin (12 mg/kg/day) remarkably suppresses the growth of A549 xenografts in nude mice. In vivo, microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. A single dose of Inulicin (12 mg/kg/day, i.p.) dramatically inhibits the growth of A549 xenografts in nude mice. Further, the weights of Inulicin-treated tumors are remarkably lighter than that of vehicle-treated tumors [1].
Cell Research
HUVECs or A549 cells are plated in 60 mm plates (300 cells/plate). After overnight incubation, cells are treated with applied agents (Inulicin; 5 μM and 10 μM) for 24 h. Cells are then washed, and fresh media are added. After 10 days of incubation, surviving colonies are fixed, stained, and manually counted [1].
Animal Research
Male nude mice (4-6weeks old, BALB/c) are used. A549 cells (five million cells in 0.1 mL of culture medium) are subcutaneously injected at the right thigh of nude mice, and treatment is started when the tumors reach an average volume of about 100 mm3. Animals are randomized into two groups with 10 mice per group: (a) Vehicle; (b) 12 mg/kg of Inulicin. Inulicin is injected intraperitoneally (i.p.) daily. The mice are examined daily for toxicity/mortality relevant to treatment, and the tumor is measured with a caliper every two days. The tumor volume (in mm3) is calculated, and the tumor growth curve is presented. At the end of experiments, xenograft tumors are isolated through surgery and weighted [1].
Synonyms 1-O-Acetylbritannilactone
Purity
Molecular Weight 308.37
Formula C17H24O5
CAS No. 33627-41-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Ethanol: 45 mg/mL (145.93 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Zhengfu H, et al. 1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling. Biochem Biophys Res Commun. 2015 Aug 21;464(2):422-7. 2. Liu YP, et al. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response. Eur J Pharmacol. 2007 Dec 22;577(1-3):28-34.

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