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Odanacatib

Catalog No. T6035 CAS 603139-19-1

Synonyms: MK-0822, MK-0822

Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Odanacatib, CAS 603139-19-1

Pack Size	Availability	Price/USD
1 mg	In stock	47.00
2 mg	In stock	86.00
5 mg	In stock	108.00
10 mg	In stock	171.00
25 mg	In stock	324.00
50 mg	In stock	432.00
1 mL * 10 mM (in DMSO)	In stock	121.00

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Purity 99.92%

HNMR HPLC COA

Purity 98.93%

HNMR HPLC COA

Purity 98.00%

HNMR COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Preparing Solutions

Description	Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
Targets&IC50	Cathepsin K (human) , Cathepsin K (rabbit)

Synonyms	MK-0822 , MK-0822
Purity	99.92%
Molecular Weight	525.56
Formula	C25H27F4N3O3S
CAS No.	603139-19-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 93 mg/mL (177 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

30% PEG400+0.5% Tween80+5% propylene glycol: 15 mg/mL

Citations

References and Literature

1. Gauthier JY, et al. Bioorg Med Chem Lett. 2008, 18(3), 923-928. 2. Leung P, et al. Bone. 2011, 49(4), 623-635. 3. Pennypacker BL, et al. J Bone Miner Res. 2011, 26(2):252-262. 4. Masarachia PJ, et al. J Bone Miner Res. 2012, 27(3), 509-523. 5. Yi C, et al. Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised rats. Sci Rep. 2017 Mar 17;7:44682.

Related compound libraries

This product is contained In the following compound libraries：

Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Clinical Compound Library Endocrinology-Hormone Compound Library Protease Inhibitor Library Immunology/Inflammation Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Fluorochemical Library Anti-Metabolism Disease Compound Library Anti-Aging Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library

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You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.